{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:49:57Z","timestamp":1784170197313,"version":"3.55.0"},"reference-count":5,"publisher":"BMJ","issue":"4","funder":[{"name":"NHS Research Scotland","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Catherine McEwan Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2019,6,13]]},"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>This case series describes the cases of three adolescent patients with established inflammatory bowel disease (IBD) who experienced significant hypophosphataemia following intravenous infusion of ferric carboxymaltose as treatment for iron deficiency anaemia. Hypophosphataemia may cause a diverse range of symptoms and may be difficult to diagnose clinically due to their non-specific nature. Checking a baseline phosphate (PO<jats:sub>4<\/jats:sub>) prior to intravenous iron infusion may identify patients at higher risk for significant hypophosphataemia and perhaps allow the selection of an alternative iron preparation. The routine monitoring of PO<jats:sub>4<\/jats:sub> levels postinfusion presents a greater challenge; with cases of asymptomatic hypophosphataemia likely to be uncovered, as in case 3. Clinicians, patients and families should be aware of the symptoms of hypophosphataemia, and symptomatic patients should have bloods checked to allow prompt identification and correction of abnormalities where required. Review of guidelines surrounding intravenous iron infusion and management of hypophosphataemia in paediatric patients is now required.<\/jats:p>","DOI":"10.1136\/flgastro-2019-101242","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T17:15:27Z","timestamp":1562174127000},"page":"324-326","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Severe hypophosphataemia following ferric carboxymaltose infusion in paediatric patients with inflammatory bowel disease"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-3487","authenticated-orcid":false,"given":"Rachel Elizabeth","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Crosshouse, Kilmarnock, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki","family":"Garrick","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gervais","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Tayler","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"2025090709142296000_11.4.324.1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1319"},{"key":"2025090709142296000_11.4.324.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167146","article-title":"Choice of high-dose intravenous iron preparation determines hypophosphatemia risk","volume":"11","author":"Schaefer","year":"2016","journal-title":"PLoS One"},{"key":"2025090709142296000_11.4.324.3","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/bcp.13189","article-title":"Drug-specific hypophosphatemia and hypersensitivity reactions following different intravenous iron infusions","volume":"83","author":"Bager","year":"2017","journal-title":"Br J Clin Pharmacol"},{"key":"2025090709142296000_11.4.324.4","doi-asserted-by":"crossref","unstructured":"Anand G , Schmid C . Severe hypophosphataemia after intravenous iron administration. BMJ Case Reports [Internet], 2017. Available: https:\/\/casereports.bmj.com\/content\/2017\/bcr-2016-219160 [Accessed 7 March 2019].","DOI":"10.1136\/bcr-2016-219160"},{"key":"2025090709142296000_11.4.324.5","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31829ed855"}],"container-title":["Frontline Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/flgastro-2019-101242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:14:35Z","timestamp":1757261675000},"score":1,"resource":{"primary":{"URL":"https:\/\/fg.bmj.com\/lookup\/doi\/10.1136\/flgastro-2019-101242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,6,6]]},"published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1136\/flgastro-2019-101242"],"URL":"https:\/\/doi.org\/10.1136\/flgastro-2019-101242","relation":{},"ISSN":["2041-4137","2041-4145"],"issn-type":[{"value":"2041-4137","type":"print"},{"value":"2041-4145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,3]]}}}