{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:32:30Z","timestamp":1757619150119,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"2","funder":[{"name":"Catherine McEwan Foundation"},{"name":"NHS Research Scotland"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2019,8,11]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>We describe the case of a patient with congenital chloride-losing diarrhoea (CCLD), global developmental delay and intermittent transaminitis who was diagnosed with Crohn\u2019s disease after persistent anaemia and onset of rectal bleeding. CCLD is a rare autosomal recessive condition causing large-volume chloride-rich diarrhoea, metabolic alkalosis and potentially life-threatening electrolyte disturbance. A possible association between CCLD and inflammatory bowel disease (IBD) has recently become apparent; however, the underlying mechanism has not been identified, with the role of increased expression of tumour necrosis factor-alpha hypothesised. Early diagnosis and management are key for favourable outcomes within both CCLD and IBD, and understanding a potential link between the two conditions may lead to development of novel therapies and management strategies. We aim to highlight the pathophysiology, diagnosis and management of CCLD; its potential association with IBD; and the potential therapeutic difficulties within the management of patients with comorbid CCLD and IBD.<\/jats:p>","DOI":"10.1136\/flgastro-2019-101283","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T17:15:50Z","timestamp":1566234950000},"page":"151-153","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Congenital chloride-losing diarrhoea and Crohn\u2019s disease: a diagnostic and therapeutic challenge"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-3487","authenticated-orcid":false,"given":"Rachel Elizabeth","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Tayler","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"2025090707575172000_12.2.151.1","doi-asserted-by":"publisher","DOI":"10.1086\/301998"},{"key":"2025090707575172000_12.2.151.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000214161.37574.9a"},{"key":"2025090707575172000_12.2.151.3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-2036.2009.04197.x","article-title":"Review article: the clinical management of congenital chloride diarrhoea","volume":"31","author":"Wedenoja","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"2025090707575172000_12.2.151.4","doi-asserted-by":"crossref","DOI":"10.1016\/j.dld.2016.08.074","article-title":"Potential association between congenital chloride diarrhea and inflammatory bowel disease","volume":"48","author":"Norsa","year":"2016","journal-title":"Dig Liver Dis"},{"key":"2025090707575172000_12.2.151.5","first-page":"1224","article-title":"Tumor necrosis factor-\u03b1 acts reciprocally with solute carrier family 26, member 3, (downregulated-in-adenoma) and reduces its expression, leading to intestinal inflammation","volume":"41","author":"Ding","year":"2018","journal-title":"Int J Mol Med"}],"container-title":["Frontline Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/flgastro-2019-101283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T14:57:57Z","timestamp":1757257077000},"score":1,"resource":{"primary":{"URL":"https:\/\/fg.bmj.com\/lookup\/doi\/10.1136\/flgastro-2019-101283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,19]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,5]]},"published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1136\/flgastro-2019-101283"],"URL":"https:\/\/doi.org\/10.1136\/flgastro-2019-101283","relation":{},"ISSN":["2041-4137","2041-4145"],"issn-type":[{"type":"print","value":"2041-4137"},{"type":"electronic","value":"2041-4145"}],"subject":[],"published":{"date-parts":[[2019,8,19]]}}}