{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:52:00Z","timestamp":1766267520690,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2020,2,12]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>New British Society of Gastroenterology\/UK-PSC guidelines have recently discussed the current state-of-the-art on primary sclerosing cholangitis and outlined key elements for the management of this disease. The current lack of effective pharmacological treatments to prevent progression of liver fibrosis to cirrhosis limits our ability to modify the natural history of the disease. However, a personalised approach and structured follow-up could allow earlier diagnosis and management of complications and favour access to liver transplantation, which remains the only available treatment. Our commentary overviews the updates and summarises the key recommendations of the recent guidelines for the management of primary sclerosing cholangitis.<\/jats:p>","DOI":"10.1136\/flgastro-2019-101343","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T17:19:48Z","timestamp":1583169588000},"page":"62-66","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Guideline review: British Society of Gastroenterology\/UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis"],"prefix":"10.1136","volume":"12","author":[{"given":"Alberto","family":"Nicoletti","sequence":"first","affiliation":[{"name":"Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free London NHS Foundation Trust, London, UK"},{"name":"Internal Medicine, Gastroenterology and Hepatology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-5328","authenticated-orcid":false,"given":"James B","family":"Maurice","sequence":"additional","affiliation":[{"name":"Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Thorburn","sequence":"additional","affiliation":[{"name":"Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"2025090709214970000_12.1.62.1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317993"},{"key":"2025090709214970000_12.1.62.2","unstructured":"NHS Blood and Transplant . 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