{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:34:49Z","timestamp":1757619289385,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2021,5,1]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>The lipodystrophies are an extremely rare group of metabolic conditions which are categorised based on their pathogenesis and phenotype. While primarily known for the striking loss of subcutaneous adipose tissue which they induce, they may also be associated with significant liver injury. In most cases, this results from the secondary deposition of lipid within hepatic parenchyma and is seen predominantly in generalised lipodystrophy. More rarely, patients may develop autoimmune hepatitis. We report a rare case of a 17-month-old boy who developed features of acquired partial lipodystrophy in association with anti-LKM1-positive autoimmune hepatitis following initial presentation with a Henoch-Sch\u00f6nlein purpura-like illness. We describe his challenging path to diagnosis and discuss his ongoing management in an effort to further our understanding of this rare but significant association. This report highlights the need for close clinical observation and a high index of suspicion for recognising early features of lipodystrophy.<\/jats:p>","DOI":"10.1136\/flgastro-2021-101824","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T13:26:40Z","timestamp":1620998800000},"page":"175-177","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Autoimmune hepatitis and acquired partial lipodystrophy"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7402-1408","authenticated-orcid":false,"given":"Christopher","family":"Bakewell","sequence":"first","affiliation":[{"name":"Paediatric Gastroenterology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavinda","family":"Dayasiri","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astor","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Williams","sequence":"additional","affiliation":[{"name":"National Severe Insulin Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish L","family":"Gupte","sequence":"additional","affiliation":[{"name":"Liver Unit (including Small Bowel Transplantation), Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"2025090709503730000_13.2.175.1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S130810"},{"key":"2025090709503730000_13.2.175.2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1159\/000495767","article-title":"Fatty liver and autoimmune hepatitis: two forms of liver involvement in lipodystrophies","volume":"26","author":"Ribeiro","year":"2019","journal-title":"GE Port J Gastroenterol"},{"key":"2025090709503730000_13.2.175.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000111061.69212.59"},{"key":"2025090709503730000_13.2.175.4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1542\/peds.33.4.593","article-title":"The syndromes of total lipodystrophy and of partial lipodystrophy","volume":"33","author":"Senior","year":"1964","journal-title":"Pediatrics"},{"key":"2025090709503730000_13.2.175.5","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1210\/jc.2015-3722","article-title":"Progressive generalized lipodystrophy as a manifestation of autoimmune polyglandular syndrome type 1","volume":"101","author":"Sorkina","year":"2016","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Frontline Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/flgastro-2021-101824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:50:44Z","timestamp":1757263844000},"score":1,"resource":{"primary":{"URL":"https:\/\/fg.bmj.com\/lookup\/doi\/10.1136\/flgastro-2021-101824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,14]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,7]]},"published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1136\/flgastro-2021-101824"],"URL":"https:\/\/doi.org\/10.1136\/flgastro-2021-101824","relation":{},"ISSN":["2041-4137","2041-4145"],"issn-type":[{"type":"print","value":"2041-4137"},{"type":"electronic","value":"2041-4145"}],"subject":[],"published":{"date-parts":[[2021,5,14]]}}}