{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:09:17Z","timestamp":1788282557588,"version":"build-2803163510"},"reference-count":54,"publisher":"BMJ","issue":"e1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2022,5,3]]},"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Lynch syndrome (LS) is a dominantly inherited cancer susceptibility syndrome defined by presence of pathogenic variants in DNA mismatch repair genes <jats:italic>MLH1<\/jats:italic>, <jats:italic>MSH2<\/jats:italic>, <jats:italic>MSH6<\/jats:italic> and <jats:italic>PMS2<\/jats:italic>, or in deletions of the <jats:italic>EPCAM<\/jats:italic> gene. Although LS is present in about 1 in 400 people in the UK, it estimated that only 5% of people with this condition are aware of the diagnosis. Therefore, testing for LS in all new diagnoses of colorectal or endometrial cancers is now recommended in the UK, and gastroenterologists can offer \u2018mainstreamed\u2019 genetic testing for LS to patients with cancer. Because LS results in a high lifetime risk of colorectal, endometrial, gastric, ovarian, hepatobiliary, brain and other cancers, the lifelong care of affected individuals and their families requires a coordinated multidisciplinary approach. Interventions such as high-quality 2-yearly colonoscopy, prophylactic gynaecological surgery, and aspirin are proven to prevent and facilitate early diagnosis and prevention of cancers in this population, and improve patient outcomes. Recently, an appreciation of the mechanism of carcinogenesis in LS-associated cancers has contributed to the development of novel therapeutic and diagnostic approaches, with a gene-specific approach to disease management, with potential cancer-preventing vaccines in development. An adaptive approach to surgical or oncological management of LS-related cancers may be considered, including an important role for novel checkpoint inhibitor immunotherapy in locally advanced or metastatic disease. Therefore, a personalised approach to lifelong gene-specific management for people with LS provides many opportunities for cancer prevention and treatment which we outline in this review.<\/jats:p>","DOI":"10.1136\/flgastro-2022-102123","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T13:21:45Z","timestamp":1654176105000},"page":"e80-e87","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Diagnosis and management of Lynch syndrome"],"prefix":"10.1136","volume":"13","author":[{"given":"Penelope","family":"Edwards","sequence":"first","affiliation":[{"name":"Gastrointestinal and Lymphoma Units, Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-4003","authenticated-orcid":false,"given":"Kevin J","family":"Monahan","sequence":"additional","affiliation":[{"name":"Lynch Syndrome Clinic, The Centre for Familial Intestinal Cancer, St Marks Hospital, London, UK"},{"name":"Faculty of Medicine, Department of Surgery & Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"2025090708553864000_13.e1.e80.1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.3959","article-title":"Association of rare pathogenic DNA variants for familial hypercholesterolemia, hereditary breast and ovarian cancer syndrome, and Lynch syndrome with disease risk in adults according to family history","volume":"3","author":"Patel","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2025090708553864000_13.e1.e80.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.018"},{"key":"2025090708553864000_13.e1.e80.3","unstructured":"Pected cancer: recognition and referral NICE guideline [NG12] [Internet]. 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