{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:06:59Z","timestamp":1790968019438,"version":"4.1.0"},"reference-count":34,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Fam Med Com Health"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Understanding the side effects and acceptability of thermal ablation (TA) is necessary before large-scale application in screen-and-treat programmes can be justified in low-income and middle-income countries (LMICs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Articles were selected for inclusion by two independent reviewers. Risk of bias was assessed using the Downs and Black\u2019s criteria. Summary data were extracted, and authors contacted for data when necessary. Proportions of interest and 95% CIs were estimated using a random effects model. Subgroup analysis was performed based on place of treatment and timing of post-treatment follow-up. Heterogeneity was estimated using the I<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Eligibility criteria<\/jats:title><jats:p>Studies that reported one or more side effects or patient acceptability measures after treatment of the cervix using TA in women living in LMICs who completed a cervical cancer screening test. Included articles were clinical trials or observational studies available in English and published before 18 December 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Information sources<\/jats:title><jats:p>Ovid MEDLINE, EMBASE, CINAHL, CAB Global Health and WHO Global Index Medicus were searched for this systematic review and meta-synthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1590 abstracts were screened, 84 full text papers reviewed and 15 papers selected for inclusion in the qualitative review, 10 for meta-synthesis (N=2039). Significant heterogeneity was found in screening tests used to identify women eligible for TA and in methods to ascertain side effects. The most commonly reported side effect during treatment was pain (70%, 95%\u2009CI 52% to 85%; I<jats:sup>2<\/jats:sup>=98.01%) (8 studies; n=1454). No women discontinued treatment due to pain. At treatment follow-up, common side effects included vaginal discharge (72%, 95%\u2009CI 18% to 100%; I<jats:sup>2<\/jats:sup>=99.55%) (5 studies; n=771) and bleeding (38%, 95%\u2009CI 15% to 64%; I<jats:sup>2<\/jats:sup>=98.14%) (4 studies; n=856). Satisfaction with treatment was high in 99% (95% CI 98% to 100%; I<jats:sup>2<\/jats:sup>=0.00%) of women (3 studies; n=679).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TA results in a number of common side effects, though acceptability remains high among women treated in LMICs. Standardised side effect and acceptability reporting are needed as TA becomes more readily available.<\/jats:p><\/jats:sec><jats:sec><jats:title>PROSPERO registration number<\/jats:title><jats:p>CRD42020197605.<\/jats:p><\/jats:sec>","DOI":"10.1136\/fmch-2021-001541","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T16:11:22Z","timestamp":1651853482000},"page":"e001541","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Side effects and acceptability measures for thermal ablation as a treatment for cervical precancer in low-income and middle-income countries: a systematic review and meta-synthesis"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"isrctn12767014","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9569-4989","authenticated-orcid":false,"given":"Evelyne Marie","family":"Piret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie W","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Trawin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Orem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Nakisige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"2022050609101213000_10.2.e001541.1","unstructured":"WHO . Global strategy to accelerate the elimination of cervical cancer as a public health problem. Geneva: World Health Organization, 2020."},{"key":"2022050609101213000_10.2.e001541.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050132"},{"key":"2022050609101213000_10.2.e001541.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30298-3"},{"key":"2022050609101213000_10.2.e001541.4","unstructured":"WHO . WHO guidelines for screening and treatment of precancerous lesions for cervical cancer prevention. Geneva: World Health Organization, 2013."},{"key":"2022050609101213000_10.2.e001541.5","unstructured":"WHO . WHO guidelines for the use of thermal ablation for cervical pre-cancer lesions. Geneva: World Health Organization, 2019."},{"key":"2022050609101213000_10.2.e001541.6","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2016.003731"},{"key":"2022050609101213000_10.2.e001541.7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ijgo.12904","article-title":"A systematic review and meta-analysis of thermal coagulation compared with cryotherapy to treat precancerous cervical lesions in low- and middle-income countries","volume":"147","author":"de Fouw","year":"2019","journal-title":"Int J Gynaecol Obstet"},{"key":"2022050609101213000_10.2.e001541.8","unstructured":"WHO . WHO technical guidance and specifications of medical devices for screening and treatment of precancerous lesions in the prevention of cervical cancer. Geneva: World Health Organization, 2020."},{"key":"2022050609101213000_10.2.e001541.9","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.31557\/APJCP.2020.21.5.1391","article-title":"A prospective randomized trial to compare safety, acceptability and efficacy of thermal ablation and cryotherapy in a screen and treat setting","volume":"21","author":"Banerjee","year":"2020","journal-title":"Asian Pac J Cancer Prev"},{"key":"2022050609101213000_10.2.e001541.10","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835b1041"},{"key":"2022050609101213000_10.2.e001541.11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1470-2045(19)30635-7","article-title":"Thermal ablation versus cryotherapy or loop excision to treat women positive for cervical precancer on visual inspection with acetic acid test: pilot phase of a randomised controlled trial","volume":"21","author":"Pinder","year":"2020","journal-title":"Lancet Oncol"},{"key":"2022050609101213000_10.2.e001541.12","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/ijc.33290","article-title":"Efficacy of point-of-care thermal ablation among high-risk human papillomavirus positive women in China","volume":"148","author":"Zhao","year":"2021","journal-title":"Int J Cancer"},{"key":"2022050609101213000_10.2.e001541.13","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2020.834"},{"key":"2022050609101213000_10.2.e001541.14","unstructured":"Covidence systematic review software. Melbourne, Australia: veritas health innovation 2021."},{"key":"2022050609101213000_10.2.e001541.15","unstructured":"World Bank . World bank country and lending groups. Available: https:\/\/datahelpdesk.worldbank.org\/knowledgebase\/articles\/906519-world-bank-country-and-lending-groups [Accessed Jan 2021]."},{"key":"2022050609101213000_10.2.e001541.16","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"2022050609101213000_10.2.e001541.17","unstructured":"StataCorp . Stata statistical software: release 15. 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