{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:52:08Z","timestamp":1793638328143,"version":"4.5.1"},"reference-count":40,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"unspecified","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERESP Network- Intramural (ESP22PI08)"],"award-info":[{"award-number":["CIBERESP Network- Intramural (ESP22PI08)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Miguel Servet contract (CP22\/00029) to Ignacio Azn"],"award-info":[{"award-number":["Miguel Servet contract (CP22\/00029) to Ignacio Azn"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Fam Med Com Health"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Long-term use of benzodiazepines (BZD) triggers health problems. Although Spain leads European use of BZD, the number of long-term users (LTUs) remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of the study is to estimate the proportion of primary care (PC) patients who initiate a BDZ prescription that subsequently become LTU and to identify its associated factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective real-world data cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting and participant<\/jats:title>\n                  <jats:p>It included the population over 15 years with a new prescription of BZD in PC in Catalonia. Users were considered LTU if they had been dispensed at least three prescriptions within 3 months. Sociodemographic characteristics of patients and prescribers, pathologies, previous BZD use, number and type of visits, and prescription quality standard were considered. We estimated the proportion of LTU among patients with a new prescription, stratified by age and sex, and estimated risk factors by multivariate generalised linear models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>100\u2009638 users with a new BZD prescription were included. 27.1% were LTU at 3 months and 14.5% at 6 months. LTU increases with age and is higher in women. Predictors of LTU are Spanish nationality, living in rural areas, having a mental illness, having used BZD, having virtual visits or not meeting pharmacy-therapeutic quality standards.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The number of patients who develop LTU is high, especially in the elderly. Exploring the causes of this phenomenon could contribute to the development of future interventions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fmch-2024-003233","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T08:40:23Z","timestamp":1753951223000},"page":"e003233","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Challenge of long-term benzodiazepine use in primary care: insights from a real-world cohort study in Catalonia"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-4961","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Pe\u00f1arrubia-Mar\u00eda","sequence":"first","affiliation":[{"name":"EAP Bartomeu Fabr\u00e9s Anglada, Institut Catal\u00e0 de la Salut, IDIAP Jordi Gol, Barcelona, Catalunya, Spain"},{"name":"Universitat de Barcelona Facultat de Medicina i Ciencies de la Salut, Barcelona, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy Anne","family":"Parker","sequence":"additional","affiliation":[{"name":"Departamento de Salud P\u00fablica, Historia de la Ciencia y Ginecolog\u00eda, Universidad Miguel Hern\u00e1ndez, Alicante, Spain"},{"name":"Consorcio de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3259-9524","authenticated-orcid":false,"given":"Marta","family":"Puig-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Salud P\u00fablica, Historia de la Ciencia y Ginecolog\u00eda, Universidad Miguel Hern\u00e1ndez, Alicante, Spain"},{"name":"Consorcio de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, 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