{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:24:03Z","timestamp":1783347843978,"version":"3.54.6"},"reference-count":45,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Fam Med Com Health"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the design, structure and first-year operational data of the Precision Medicine Clinic (PMC) at King Faisal Specialist Hospital &amp; Research Centre (KFSHRC), a primary-care-embedded genomic medicine service launched in Riyadh, Saudi Arabia, in January 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Descriptive service report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The Precision Medicine Clinic, an embedded subspecialty service within the Department of Family Medicine and Polyclinics at KFSHRC\u2014a publicly funded, single-payer tertiary academic centre in Riyadh, Saudi Arabia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participant<\/jats:title>\n                    <jats:p>Adult and paediatric patients evaluated at the PMC during its first calendar year of operation (January\u2013December 2025), referred from primary care for predictive genomic testing, pharmacogenomic testing or genetic counselling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>The PMC evaluated 212 patients in 2025. Predictive genomic testing accounted for approximately 57% of evaluations and pharmacogenomics for approximately 43%, indicating a genuinely hybrid first-year caseload rather than one dominated by a single modality. Turnaround time from referral to results delivery was approximately 2\u20134 months. The predominant care model was two-visit (family-history capture and consent at visit 1; results disclosure at visit 2). Distinguishing features include embedding within a fully operational family-medicine department, a hybrid service scope spanning reactive pharmacogenomics, predictive Centres for Disease Control and Prevention (CDC) tier-1 actionable-gene screening and reproductive carrier screening under a single referral interface, integration with the Saudi Human Genome Program (SHGP) reference catalogue, and operation during the first year without routine medical-geneticist involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PMC-KFSHRC offers a replicable organisational template for integrating genomic medicine into primary care within a publicly funded, single-payer system and a reference architecture for Gulf and emerging-economy health systems pursuing primary-care genomic integration under Vision 2030\u2014aligned digital-health strategies.<\/jats:p>\n                  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