{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:34:41Z","timestamp":1787240081195,"version":"build-2736575974"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>High frequency oscillation (HFO) as rescue treatment for preterm infants with severe respiratory failure has been assessed and prognostic factors identified. Thirty six infants with a median gestational age of 27 weeks were studied. Immediately before transfer to HFO, the infants were receiving an inspired oxygen concentration of &gt; or = 85% and\/or a mean airway pressure of &gt; or = 12 cm H2O and had a median alveolar-arterial oxygen gradient (A-aDO2) of 73.28 kPa (range 49.34-89.91). Seventeen infants subsequently died. Comparison of those 17 with the remaining 19 infants demonstrated that respiratory distress syndrome and persistent fetal circulation were associated with a significantly better outcome than pulmonary airleak. The A-aDO2 after two and six hours on HFO was significantly higher in those infants who survived compared with those who died. We conclude that a diagnosis of pulmonary airleak and failure to show early improvement in respiratory status indicate a poor prognosis when HFO is used as rescue treatment.<\/jats:p>","DOI":"10.1136\/fn.70.1.f44","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T17:55:51Z","timestamp":1225475751000},"page":"F44-F46","source":"Crossref","is-referenced-by-count":18,"title":["High frequency oscillation for preterm infants with severe respiratory failure."],"prefix":"10.1136","volume":"70","author":[{"given":"V","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H R","family":"Gamsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"ref_1","first-page":"693","article-title":"Neonatal complications of mechanical ventilation in extremely preterm infants","volume":"151","author":"Chan, V.; Greenough, A.; Gamsu, H.R.","year":"1992","unstructured":"Chan V, Greenough A, Gamsu HR. Neonatal complications of mechanical ventilation in extremely preterm infants. EurJPediatr 1992; 151: 693-6.","journal-title":"EurJPediatr"},{"key":"ref_2","first-page":"394","article-title":"Extracorporeal membrane oxygenation and other new modes of gas exchange","volume-title":"respiratory failure","author":"Nicks, J.J.; Bartlett, R.H.","year":"1988","unstructured":"Nicks JJ, Bartlett RH. Extracorporeal membrane oxygenation and other new modes of gas exchange. In: Carlo WA, Chatburn RL, eds. Neonatal respiratory failure. Chicago: Year Book Medical Publishers 1988: 394-407."},{"key":"ref_3","first-page":"236","article-title":"Extracorporeal membrane oxygenation (ECMO) in neonatal respiratory failure. 100 cases","volume":"204","author":"Bartlett, R.H.; Gazzaniga, A.B.; Toomasian, J.; Coran, A.G.; Roloff, D.; Rucker, R.","year":"1986","unstructured":"Bartlett RH, Gazzaniga AB, Toomasian J, Coran AG, Roloff D, Rucker R. Extracorporeal membrane oxygenation (ECMO) in neonatal respiratory failure. 100 cases. Ann Surg 1986; 204: 236-45."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1542\/peds.89.1.5","article-title":"Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome","volume":"89","author":"Clark, R.H.; Gerstmann, D.R.; DM, Jr, Null; DeLemos, R.A.","year":"1992","unstructured":"Clark RH, Gerstmann DR, Null DM Jr, DeLemos RA. Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome. Pediatrics 1992; 89: 5-12.","journal-title":"Pediatrics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1056\/NEJM198901123200204","article-title":"High frequency oscillatory ventilation compared with conventional intermittent mechanical ventilation in the treatment of respiratory failure in premature neonates","volume":"320","author":"Group, The H.I.F.I.Study","year":"1989","unstructured":"The HIFI Study Group. High frequency oscillatory ventilation compared with conventional intermittent mechanical ventilation in the treatment of respiratory failure in premature neonates. NEnglJMed 1989; 320: 88-93.","journal-title":"NEnglJMed"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/BF01956752","article-title":"Determinants ofoxygenation during high frequency oscillation","volume":"152","author":"Chan, V.; Greenough, A.","year":"1993","unstructured":"Chan V, Greenough A. Determinants ofoxygenation during high frequency oscillation. Eur J Pediatr 1993; 152: 350-3.","journal-title":"Eur J Pediatr"},{"key":"ref_7","first-page":"297","article-title":"Criteria for extracorporeal membrane oxygenation in a population of infants with persistent pulmonary hypertension of the newborn","volume":"21","author":"Beck, R.; Anderson, K.D.; Pearson, G.D.; Cronin, J.; Miller, M.K.; Short, B.L.","year":"1986","unstructured":"Beck R, Anderson KD, Pearson GD, Cronin J, Miller MK, Short BL. Criteria for extracorporeal membrane oxygenation in a population of infants with persistent pulmonary hypertension of the newborn. J Pediatr 1986; 21: 297-302.","journal-title":"J Pediatr"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/BF00496418","article-title":"High frequency oscillatory ventilation combined with intermittent mandatory ventilation in critically ill neonates","volume":"147","author":"Blum-Hoffman, E.; Kopotic, R.J.; Mannino, F.L.","year":"1988","unstructured":"Blum-Hoffman E, Kopotic RJ, Mannino FL. High frequency oscillatory ventilation combined with intermittent mandatory ventilation in critically ill neonates. Eur J Pediatr 1988; 147: 392-8.","journal-title":"Eur J Pediatr"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ppul.1950120108","article-title":"Rescue ventilation with high frequency oscillation in premature baboons with hyaline membrane disease","volume":"12","year":"1992","unstructured":"DeLemos RA, Coalson JJ, DeLemos JA, King RJ, Clark RH, Gerstmann DR. Rescue ventilation with high frequency oscillation in premature baboons with hyaline membrane disease. Pediatr Pulmonol 1992; 12: 29-36.","journal-title":"Pediatr Pulmonol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary disease following respirator therapy of hyaline membrane disease","volume":"267","author":"Northway, W.H.; Rosan, R.C.; Porter, D.Y.","year":"1967","unstructured":"Northway WH, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline membrane disease. 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