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Direct head to head clinical trials will probably be necessary to establish appropriate criteria and indications for use, given the wide diversity of pathophysiology these unique patients present.<\/jats:p>","DOI":"10.1136\/fn.70.2.f81","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T17:55:51Z","timestamp":1225475751000},"page":"F81-F83","source":"Crossref","is-referenced-by-count":7,"title":["Alternatives to ECMO."],"prefix":"10.1136","volume":"70","author":[{"given":"S M","family":"Donn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"ref_1","first-page":"143","article-title":"ECMO indications and complications. Hosp Prac","volume":"25","author":"Donn, S.M.","year":"1990","unstructured":"Donn SM. ECMO indications and complications. Hosp Prac 1990; 25: 143-57."},{"article-title":"Extracorporeal Life Support Organization. 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Extracorporeal membrane oxygenation and other new modes of gas exchange. In: Carlo WA, Chatburn RL, eds. Neonatal respiratory care. Chicago: Year Book Medical Publishers, 1988: 394-408."},{"key":"ref_6","first-page":"279","article-title":"Persistent pulmonary hypertension of the newborn","author":"Deluga, K.S.","year":"1991","unstructured":"Deluga KS. Persistent pulmonary hypertension of the newborn. In: Donn SM, Faix RG, eds. Neonatal emergencies. Mount Kisco, NY: Futura Publishing, 1991: 279-96."},{"key":"ref_7","first-page":"1005","article-title":"Physiologic factors affecting pulmonary artery pressure in infants with persistent pulmonary hypertension","volume":"93","author":"Peckham, G.J.; Fox, W.W.","year":"1978","unstructured":"Peckham GJ, Fox WW. Physiologic factors affecting pulmonary artery pressure in infants with persistent pulmonary hypertension. 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Proceedings of the seventh conference on high frequency ventilation ofinfants","author":"Hart, M.; Finley, V.; Wales, R.","year":"1990","unstructured":"Hart M, Finley V, Wales R. High frequency jet ventilation and persistent pulmonary hypertension. Proceedings of the seventh conference on high frequency ventilation ofinfants. Snowbird, Utah, April 1990."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1542\/peds.85.2.159","article-title":"High-frequency oscillatory ventilation and extracorporeal membrane oxygenation for the treatment of acute neonatal respiratory failure","volume":"85","author":"Carter, J.M.; Gerstmann, D.R.; Clark, R.H.","year":"1990","unstructured":"Carter JM, Gerstmann DR, Clark RH, et al. High-frequency oscillatory ventilation and extracorporeal membrane oxygenation for the treatment of acute neonatal respiratory failure. 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