{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:39:53Z","timestamp":1791938393518,"version":"4.3.4"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>This study documents the presentation of acutely life threatening congenital heart disease in infancy in order to assess the performance of screening examinations soon after birth and at 6 weeks of age. All cases of obstructive left heart malformations presenting in infancy in one health region from 1987-91 were analysed retrospectively. Altogether, 120 infants presented with either hypoplastic left heart syndrome, interruption of the aortic arch, coarctation of the aorta, or aortic valve stenosis. Twelve became symptomatic or died within 24 hours. Thirty four had an abnormal neonatal examination, eight of whom were referred. Six more became symptomatic before discharge. Ninety four babies went home, 51 developed heart failure before 6 weeks, and another seven died without diagnosis. Twenty five of 36 (69%) reaching 6 weeks without diagnosis had a second examination which was abnormal in 17. Two babies died undiagnosed after 6 weeks and the other 18 presented at up to 11 months of age. The neonatal and 6 week examinations perform poorly as screening tests for congenital heart disease. A normal neonatal examination does not exclude life threatening congenital heart disease.<\/jats:p>","DOI":"10.1136\/fn.71.3.f179","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T17:55:51Z","timestamp":1225475751000},"page":"F179-F183","source":"Crossref","is-referenced-by-count":79,"title":["Presentation of obstructive left heart malformations in infancy."],"prefix":"10.1136","volume":"71","author":[{"given":"M","family":"Abu-Harb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wyllie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Richmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/adc.71.1.3","article-title":"Death in infancy from unrecognised heart disease","volume":"71","author":"Abu-Harb, M.; Hey, E.; Wren, C.","year":"1994","unstructured":"Abu-Harb M, Hey E, Wren C. Death in infancy from unrecognised heart disease. Arch Dis Child 1994 1994; 71: 3-7.","journal-title":"Arch Dis Child"},{"issue":"641 -7","key":"ref_2","article-title":"Congenital heart disease in a cohort of 19 502 births with long term follow up","volume":"42","author":"Hoffman, J.I.E.; Christianson, R.","year":"1978","unstructured":"Hoffman JIE, Christianson R. Congenital heart disease in a cohort of 19 502 births with long term follow up. Am J Cardiol 1978; 42: 641 -7.","journal-title":"Am J Cardiol"},{"key":"ref_3","article-title":"A programme for child health surveillance","author":"Hall DMB. Health for all children","year":"1991","unstructured":"Hall DMB. Health for all children. A programme for child health surveillance. Oxford: Oxford University Press, 1991."},{"key":"ref_4","article-title":"Essential public health medicine","author":"Donaldson, R.J.; Donaldson, U.","year":"1993","unstructured":"Donaldson RJ, Donaldson U. Essential public health medicine. Dordrecht: Kluwer, 1993."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/adc.67.7_Spec_No.770","article-title":"Northern Regional Survey Steering Group. Fetal abnormality: an audit of its recognition and management","volume":"67","year":"1992","unstructured":"Northern Regional Survey Steering Group. Fetal abnormality: an audit of its recognition and management. Arch Dis Child 1992; 67: 770-4.","journal-title":"Arch Dis Child"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1136\/bmj.288.6432.1717","article-title":"Northern Regional Health Authority Co-ordinating Group. Perinatal mortality: a continuing collaborative regional survey","volume":"288","year":"1984","unstructured":"Northern Regional Health Authority Co-ordinating Group. Perinatal mortality: a continuing collaborative regional survey. BMJ 1984; 288: 1717-20.","journal-title":"BMJ"},{"key":"ref_7","article-title":"The first year of life","author":"Valman, H.B.","year":"1989","unstructured":"Valman HB. The first year of life. London: British Medical Association, 1989."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1136\/bmj.302.6781.878","article-title":"Routine examination in the neonatal period","volume":"302","author":"Moss, G.D.; Cartlidge, P.H.T.; Speidel, B.D.; Chambers, T.L.","year":"1991","unstructured":"Moss GD, Cartlidge PHT, Speidel BD, Chambers TL. Routine examination in the neonatal period. BMJ 1991; 302: 878-9.","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1542\/peds.86.6.972","article-title":"Delayed detection of coarctation in infancy: implications for timing of newborn follow up","volume":"86","author":"Ward, K.E.; Pryor, R.W.; Matson, JR, Razook; JD, Thompson; WM, Elkins; R.C.","year":"1990","unstructured":"Ward KE, Pryor RW, Matson JR, Razook JD, Thompson WM, Elkins RC. Delayed detection of coarctation in infancy: implications for timing of newborn follow up. Pediatrics 1990; 86: 972-6.","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1136\/bmj.302.6786.1209-c","article-title":"One or two routine neonatal examinations?","volume":"302","author":"Manning, D.J.","year":"1991","unstructured":"Manning DJ. One or two routine neonatal examinations? [letter]. BMJ 1991; 302: 1209.","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/fn.70.1.F71","article-title":"Assessment and management of congenital heart disease in the newborn by the district paediatrician","volume":"70","author":"Silove, E.D.","year":"1994","unstructured":"Silove ED. Assessment and management of congenital heart disease in the newborn by the district paediatrician. Arch Dis Child 1994; 70: F71-4.","journal-title":"Arch Dis Child"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.71.3.F179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T10:59:08Z","timestamp":1757069948000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.71.3.F179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1994,11,1]]},"published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.1136\/fn.71.3.F179"],"URL":"https:\/\/doi.org\/10.1136\/fn.71.3.f179","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11]]}}}