{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:13:52Z","timestamp":1779912832785,"version":"3.53.1"},"reference-count":25,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>As part of a study of thyroid function in premature babies, the iodine content of their mothers' breast milk, that of 32 formulas from different brands used in Spain, and that of 127 formulas used in other countries was determined. Breast milk contained more iodine--mean (SEM) 10 (1) microgram\/dl--than most of the formulas, especially those for premature babies. Iodine intakes were therefore below the recommended daily amount (RDA) for newborns: babies of 27-30 weeks' gestational age took 3.1 (1.1) micrograms\/day at 5 days of age and 29.8 (2.7) micrograms by 2 months of age. This problem is not exclusive to Spanish premature babies as the iodine content of many of the formulas on sale in other countries was also inadequate. It is concluded that preterm infants who are formula fed are at high risk of iodine deficiency.<\/jats:p>","DOI":"10.1136\/fn.71.3.f184","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T17:55:51Z","timestamp":1225475751000},"page":"F184-F191","source":"Crossref","is-referenced-by-count":39,"title":["Iodine content of infant formulas and iodine intake of premature babies: high risk of iodine deficiency."],"prefix":"10.1136","volume":"71","author":[{"given":"S","family":"Ares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Quero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Presas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Herruzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Morreale de Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(83)90636-0","article-title":"Iodine deficiency disorders (IDD) and their eradication","volume":"ii:","author":"Hetzel, B.S.","year":"1983","unstructured":"Hetzel BS. 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Recommended daily amounts","author":"Food and Nutrition Board of the National","year":"1989","unstructured":"Food and Nutrition Board of the National Academy of Sciences and National Research Council. Recommended daily amounts. 10th Edn. Washington, DC: National Academy Press, 1989: 213-17.","edition":"10th Edn"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/978-1-4899-1245-9","article-title":"Recommendations on iodine nutrition for mothers and infants in Europe","volume-title":"eds. Iodine deficiency disorders in Europe: a continuing concern","volume":"191","author":"Delange, F.","year":"1993","unstructured":"Recommendations on iodine nutrition for mothers and infants in Europe. In: Delange F, Dunn JT, Glinoer D, F191 eds. Iodine deficiency disorders in Europe: a continuing concern. New York: Plenum Press, 1993: 471-8."},{"key":"ref_6","first-page":"1","article-title":"Nutrition and feeding of preterm infants. 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Official Bulletin of the European Communities 1986; C285: 5-19.","journal-title":"Official Bulletin of the European Communities"},{"key":"ref_8","first-page":"205","article-title":"Physiopathology of Iodine nutrition during pregnancy, lactation, and early postnatal life","volume-title":"and minerals in pregnancy and lactation. Nestle Nutrition Workshop Series. Vol 16","author":"Delange, F.; Bourdoux, J.; Chanoine, P.; Ermans, A.M.","year":"1988","unstructured":"Delange F, Bourdoux J, Chanoine P, Ermans AM. Physiopathology of Iodine nutrition during pregnancy, lactation, and early postnatal life. In: Berger H, ed. Vitamins and minerals in pregnancy and lactation. Nestle Nutrition Workshop Series. Vol 16. New York: Vevey\/Raven Press, 1988: 205-13."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/978-1-4899-1245-9_1","article-title":"Requirements of iodine in humans","volume-title":"deficiency in Europe. A continuing concern","author":"Delange, F.","year":"1993","unstructured":"Delange F. Requirements of iodine in humans. In: Delange F, Dunn JT, Glinoer D, eds. Iodine deficiency in Europe. A continuing concern. New York: Plenum Press, 1993: 5-16."},{"key":"ref_10","first-page":"131","article-title":"Wawschinek 0, Ebber 0, Jodgehalt der Sauglingsnahrung in Oesterreich","volume":"20","author":"Buchinger, W.; Langsteger, W.; Tiran, B.","year":"1993","unstructured":"Buchinger W, Langsteger W, Tiran B, Wawschinek 0, Ebber 0, Jodgehalt der Sauglingsnahrung in Oesterreich. Acta Med Austr 1993; 20: 131-3.","journal-title":"Acta Med Austr"},{"key":"ref_11","first-page":"408","article-title":"A semiautomated method for the determination of the plasma","volume":"9","author":"Benotti, J.; Benotti, N.A.","year":"1963","unstructured":"Benotti J, Benotti NA. A semiautomated method for the determination of the plasma PBI. Clin Chem 1963; 9: 408-16.","journal-title":"PBI. Clin Chem"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-08-037496-3.50009-6","article-title":"Iodine nutrition and risk of thyroid irradiation from nuclear accidents","volume-title":"profylaxis folowing nuclear accidents","author":"Delange, F.","year":"1990","unstructured":"Delange F. Iodine nutrition and risk of thyroid irradiation from nuclear accidents. In: Rubery E, Smales E, eds. Iodine profylaxis folowing nuclear accidents. Oxford: Pergamon Press, 1990: 45-53."},{"key":"ref_13","article-title":"Iodine deficiency","author":"Delange, F.; Ermans, A.M.","year":"1991","unstructured":"Delange F, Ermans AM. Iodine deficiency. In: Braveman LE, Utiger RD, eds. The thyroid. A fundamental and clinical text. Philadelphia: J B Lippincott, 1991.","journal-title":"Philadelphia: J B Lippincott; The thyroid. A fundamental and clinical text"},{"key":"ref_14","first-page":"12","article-title":"Thyroid hormone and iodine intakes of bottle fed versus breast-fed babies","volume":"35","author":"Mallol, J.; Morreale, G.; Escobar del Rey, F.","year":"1988","unstructured":"Mallol J, Morreale G, Escobar del Rey F. Thyroid hormone and iodine intakes of bottle fed versus breast-fed babies. Endocrinologia 1988; 35: 12-20.","journal-title":"Endocrinologia"},{"key":"ref_15","first-page":"901","article-title":"Iodinated compounds and thyroxine binding to albumin in human breast milk","volume":"18","author":"Etling, N.; Gehin-Fouque, F.","year":"1984","unstructured":"Etling N, Gehin-Fouque F. Iodinated compounds and thyroxine binding to albumin in human breast milk. PediatrRes 1984; 18: 901-3.","journal-title":"PediatrRes"},{"key":"ref_16","first-page":"117","article-title":"Iodine and thyroid hormone levels in serum and urine of full term newborn infants","volume":"38","author":"Etling, N.; Padovani, E.; Gehin-Fouque, F.; Tato, L.","year":"1983","unstructured":"Etling N, Padovani E, Gehin-Fouque F, Tato L. Iodine and thyroid hormone levels in serum and urine of full term newborn infants. Helv Paediatr Acta 1983; 38: 117-22.","journal-title":"Helv Paediatr Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1542\/peds.73.3.354","article-title":"Breast milk iodine: Reassessment in the 1980s","volume":"73","author":"Gushurst, C.A.; Mueller, J.A.; Green, J.A.; Sedor, F.","year":"1984","unstructured":"Gushurst CA, Mueller JA, Green JA, Sedor F. Breast milk iodine: Reassessment in the 1980s. Pediatrics 1984; 73: 354-7.","journal-title":"Pediatrics"},{"key":"ref_18","article-title":"Composition of feeding for infants","volume-title":"and young children in Canada. Montreal: Ross Laboratories","author":"Laboratories, Ross","year":"1989","unstructured":"Ross Laboratories. Composition of feeding for infants and young children in Canada. Montreal: Ross Laboratories, 1989."},{"key":"ref_19","first-page":"317","article-title":"Iodine deficiency disorders in Europe","volume":"67","author":"Delange, F.; Burgi, H.","year":"1989","unstructured":"Delange F, Burgi H. Iodine deficiency disorders in Europe. Bull WHO 1989; 67: 317-25.","journal-title":"Bull WHO"},{"key":"ref_20","first-page":"165","article-title":"Maternal and neonatal thyroid functions in conditions of marginally low iodine intake","volume-title":"Progress in thyroid research","author":"Glinoer, D.; Laboureur, I.; Delange, F.; Bourdoux, P.; Kinthaert, J.; Grun, J.P.","year":"1991","unstructured":"Glinoer D, Laboureur I, Delange F, Bourdoux P, Kinthaert J, Grun JP, et al. Maternal and neonatal thyroid functions in conditions of marginally low iodine intake. In: Gordon A, Gross J, Hennemann G, eds. Progress in thyroid research. Rotterdam: Balkema, 1991: 165-8."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0022-3476(84)80030-X","article-title":"Increased risk of primary hypothyroidism in preterm infants","volume":"105","author":"Delange, F.; Dalhem, A.; Bourdoux, P.; Lagasse, R.; Glinoer, D.; Fisher, D.A.","year":"1984","unstructured":"Delange F, Dalhem A, Bourdoux P, Lagasse R, Glinoer D, Fisher DA, et al. Increased risk of primary hypothyroidism in preterm infants. J Pediatrics 1984; 105: 462-9.","journal-title":"J Pediatrics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/jn\/119.suppl_12.1865","article-title":"Upper limit of iodine in infants formulas","volume":"119","author":"Fisher, D.A.","year":"1989","unstructured":"Fisher DA. Upper limit of iodine in infants formulas. J Nutr 1989; 119: 1865.","journal-title":"J Nutr"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/BF03348452","article-title":"Serum thyroglobulin in newborns cord blood, in childhood and adolescence: a physiological indicator of thyroidal status","volume":"7","author":"Pacini, F.; Lari, R.; La Ricca, P.; Grasso, L.; Taddei, D.; Bardini, N.","year":"1984","unstructured":"Pacini F, Lari R, La Ricca P, Grasso L, Taddei D, Bardini N, et al. Serum thyroglobulin in newborns cord blood, in childhood and adolescence: a physiological indicator of thyroidal status. J Endocrinol Invest 1984; 7: 467-71.","journal-title":"J Endocrinol Invest"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1136\/adc.61.9.862","article-title":"Low serum thyroxine concentrations and neural maturation in preterm infants","volume":"61","author":"LS, De Vries; JZ, Heckmatt; JM, Burrin; LMS, Dubowitz; V, Dubowitz","year":"1986","unstructured":"De Vries LS, Heckmatt JZ, Burrin JM, Dubowitz LMS, Dubowitz V. Low serum thyroxine concentrations and neural maturation in preterm infants. Arch Dis Child 1986; 61: 862-6.","journal-title":"Arch Dis Child"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1136\/adc.63.10.1201","article-title":"Low plasma triiodothyronine concentrations and outcome in preterm infants","volume":"63","author":"Lucas, A.; Rennie, J.; Baker, B.A.; Morley, R.","year":"1988","unstructured":"Lucas A, Rennie J, Baker BA, Morley R. Low plasma triiodothyronine concentrations and outcome in preterm infants. 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