{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:23:22Z","timestamp":1770481402587,"version":"3.49.0"},"reference-count":21,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>AIMS--To compare treatment regimens of two widely used natural surfactant preparations Curosurf and Survanta in respiratory distress syndrome (RDS). METHODS--The effects of the two treatment regimens on gas exchange, ventilatory requirements, and 28 day outcome in infants with RDS were compared. Seventy five preterm infants (birth weight 700-1500 g) with RDS requiring artificial ventilation with an FIO2 of &gt; or = 0.4, were randomly selected at 1-24 hours of age. One group received an initial dose of Curosurf (200 mg\/kg); the other group Survanta (100 mg\/kg). Patients who remained dependent on artificial ventilation with an FIO2 of &gt; or = 0.3 received up to two additional doses of Curosurf (each of 100 mg\/kg) after 12 and 24 hours or up to three additional doses of Survanta (each of 100 mg\/kg) between six and 48 hours after the initial dose. RESULTS--There was a rapid improvement in oxygenation and ventilatory requirements were reduced in both groups. However, infants treated with Curosurf had a higher arterial:alveolar oxygen tension ratio and required a lower peak inspiratory pressure and mean airway pressure at several time points within 24 hours of randomisation (p &lt; 0.05-0.001). The incidences of pneumothorax in the Curosurf and Survanta groups were 6% and 12.5%, respectively; the corresponding figures for grades 3-4 intracerebral haemorrhage were 3% and 12.5%, respectively. Mortality was 3% in the Curosurf group and 12.5% in the Survanta group. However, these differences did not reach significance. CONCLUSION--The Curosurf treatment regimen resulted in a more rapid improvement in oxygenation than Survanta and reduced ventilatory requirements up to 24 hours after start of treatment. This was associated with a trend towards reduced incidence of serious pulmonary and non-pulmonary complications.<\/jats:p>","DOI":"10.1136\/fn.72.1.f8","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T17:55:51Z","timestamp":1225475751000},"page":"F8-13","source":"Crossref","is-referenced-by-count":102,"title":["Randomised clinical trial of two treatment regimens of natural surfactant preparations in neonatal respiratory distress syndrome."],"prefix":"10.1136","volume":"72","author":[{"given":"C. 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Pulmonary surfactant therapy. N Engl J Med 1993; 328: 861-8.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0022-3476(05)80856-X","article-title":"A multicentre randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome","volume":"123","author":"Horbar, J.D.; Wright, L.L.; Soll, R.F.; Wright, E.C.; Fanaroff, A.A.; Korones, S.B.","year":"1993","unstructured":"Horbar JD, Wright LL, Soll RF, Wright EC, Fanaroff AA, Korones SB, et al. A multicentre randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome. J Pediatr 1993; 123: 757-66.","journal-title":"J Pediatr"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.82.5.683","article-title":"Collaborative European Multicenter Study Group. 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