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RESULTS: Packed red blood cell transfusions corrected a subclinical regional tissue acidosis (low tpH) without affecting arterial pH or limb blood flow. This observation also correlated with an increase in regional oxygen delivery. The data were also suggestive of a pattern of pathological, supply dependent, oxygen delivery and are similar to other observations made in adults with adult respiratory distress syndrome. CONCLUSIONS: Packed red blood cells increase regional oxygen delivery and tissue surface pH. In contrast, colloid infusion provided no substantial cardiovascular or metabolic benefit to these patients and should be avoided when oxygen delivery is at issue and when there may be leaky pulmonary capillaries.<\/jats:p>","DOI":"10.1136\/fn.75.2.f87","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T17:55:51Z","timestamp":1225475751000},"page":"F87-F93","source":"Crossref","is-referenced-by-count":4,"title":["Effects of increased red cell mass on subclinical tissue acidosis in hyaline membrane disease."],"prefix":"10.1136","volume":"75","author":[{"given":"E F","family":"La Gamma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Auld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/clinchem\/27.5.759","article-title":"Volume of blood removed for analytical purposes during hospitalization of low birth weight infants","volume":"27","author":"Nexo, E.; Christenson, N.C.; Olesen, J.","year":"1981","unstructured":"Nexo E, Christenson NC, Olesen J. 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