{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:51:08Z","timestamp":1787507468629,"version":"build-2736575974"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1997,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>AIM<\/jats:title>\n                    <jats:p>To compare the efficacy of a colloid (5% albumin) and a crystalloid (isotonic saline) solution for treating hypotension in mechanically ventilated preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Sixty three preterm infants weighing 540 to 1950 g at birth and with gestational ages of 23 to 34 weeks, who developed hypotension (mean arterial pressure &lt; 25, 30, and 35 mm Hg for infants with birthweight &lt;1, 1-1.49, and 1.5-1.99 kg, respectively) within the first 2 hours of life, were randomly allocated to receive intravenous infusions at 10 ml\/kg of either 5% albumin (group 1, n=32) or isotonic (0.9%) saline (group 2, n=31). Inotropic support with dopamine infusion was given if the infants remained hypotensive after a total of three infusions (30 ml\/kg). Subsequent extra doses of volume expander in the form of 5% albumin was given, depending on the infant\u2019s blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      There was no difference in the volume of the test solutions required between the two groups. Outcome, as assessed by the number of infants requiring inotropic support and death or chronic lung disease, did not differ between the groups. After inotropic support, however, group 1 required significantly more volume expander to maintain normal blood pressure (median: 27.5 ml\/kg\n                      <jats:italic>vs<\/jats:italic>\n                      10 ml\/kg; P=0.0187) and had a higher mean (SEM) percentage weight gain within the first 48 hours of life (at 24 hours: 6.3(1.3)%\n                      <jats:italic>vs<\/jats:italic>\n                      3.3(0.8)%; P=0.049; at 48 hours: 5.9(1.9)%\n                      <jats:italic>vs<\/jats:italic>\n                      0.9(1.7)%; P=0.045). The difference in weight gain was significant at 48 hours even when only those infants not requiring inotropic support or extra 5% albumin were compared (group 1: 1.5(1.5)%, group 2: -4.2(1.1)%; P = 0.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Isotonic saline is as effective as 5% albumin for treating hypotension in preterm infants, and it has the additional advantage of causing less fluid retention in the first 48 hours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/fn.76.1.f43","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:48:05Z","timestamp":1239191285000},"page":"F43-F46","source":"Crossref","is-referenced-by-count":150,"title":["Randomised controlled trial of colloid or crystalloid in hypotensive preterm infants"],"prefix":"10.1136","volume":"76","author":[{"given":"King W","family":"So","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai F","family":"Fok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak C","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam L","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,1,1]]},"reference":[{"key":"2025090512374895000_76.1.F43.1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000413178","article-title":"Haemodynamic and oxygen transport effects of crystalloids and colloids in critically ill patients.","volume":"53","author":"Shoemaker","year":"1986","journal-title":"Curr Stud Hematol Blood Transfus"},{"key":"2025090512374895000_76.1.F43.2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.5.649"},{"key":"2025090512374895000_76.1.F43.3","first-page":"577","article-title":"Comparison of colloids and crystalloids in resuscitation from haemorrhagic shock.","volume":"154","author":"Poole","year":"1982","journal-title":"Surg Gynecol Obstet"},{"key":"2025090512374895000_76.1.F43.4","first-page":"506","article-title":"Crystalloid versus colloid hemodilution in man.","volume":"142","author":"Laks","year":"1976","journal-title":"Surg Gynecol Obstet"},{"key":"2025090512374895000_76.1.F43.5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1542\/peds.67.5.607","article-title":"Aortic blood pressure during the first 12 hours of life in infants with birth weight 610 to 4220 grams.","volume":"67","author":"Versmold","year":"1981","journal-title":"Pediatrics"},{"key":"2025090512374895000_76.1.F43.6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.10_Spec_No.1185"},{"key":"2025090512374895000_76.1.F43.7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00002371-199401000-00003","article-title":"A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of vascular leak syndrome associated with interleukin-2 therapy.","volume":"15","author":"Pockaj","year":"1994","journal-title":"J Immunother"},{"key":"2025090512374895000_76.1.F43.8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2044.1980.tb05094.x","article-title":"Colloid osmotic pressure.","volume":"35","author":"Bevan","year":"1980","journal-title":"Anaesthesia"},{"key":"2025090512374895000_76.1.F43.9","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1164\/ajrccm.149.5.8173749","article-title":"Effect of hypoxia on lung fluid balance in ferrets.","volume":"149","author":"White","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2025090512374895000_76.1.F43.10","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1164\/ajrccm.149.5.8173767","article-title":"Surfactant subtypes. In vitro conversion, in vivo function, and effects of serum protein.","volume":"149","author":"Ueda","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2025090512374895000_76.1.F43.11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00180100","article-title":"Alveolar surfactant and adult respiratory distress syndrome. Pathogenetic role and therapeutic prospects.","volume":"71","author":"Seeger","year":"1993","journal-title":"Clin Invest"},{"key":"2025090512374895000_76.1.F43.12","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(94)90046-9"},{"key":"2025090512374895000_76.1.F43.13","first-page":"33s","article-title":"The evolution of neonatal respiratory distress syndrome into chronic lung disease.","volume":"3(suppl)","author":"Robertson","year":"1989","journal-title":"Eur Respir J"},{"key":"2025090512374895000_76.1.F43.14","first-page":"65","article-title":"Crystalloid versus colloid fluid resuscitation: A meta-analysis of mortality.","volume":"105","author":"Velanovich","year":"1989","journal-title":"Surgery"},{"key":"2025090512374895000_76.1.F43.15","unstructured":"Bennett K Tugwell P Sackett D Haynes B (1985) Relative risks, benefits, and cost of intervention. Sackett P, Haynes B, Tugwell P,eds. Clinical epidemiology: a basic science for clinical medicine. (Little Brown, Boston), pp 205\u2013228."}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.76.1.F43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:38:00Z","timestamp":1757101080000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.76.1.F43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1997,1,1]]},"published-print":{"date-parts":[[1997,1,1]]}},"alternative-id":["10.1136\/fn.76.1.F43"],"URL":"https:\/\/doi.org\/10.1136\/fn.76.1.f43","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1,1]]}}}