{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:47:58Z","timestamp":1790704078265,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>To determine the incidence of neonatal thromboembolism in Germany.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Diagnostic imaging techniques, therapeutic modalities, and short term outcome were evaluated in a prospective nationwide two year case registry study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The reported incidence of symptomatic neonatal thromboembolism, diagnosed in most cases with Doppler ultrasonography, was 5.1 per 100\u2002000 births, with a total of 79 cases registered: renal venous thrombosis (n=35); venous thrombosis (n=25); and arterial vascular occlusion (n=19). Fifty seven of 79 thromboses were associated with additional risk factors (central line n=25, asphyxia n=13, septicaemia n=11, dehydration n=6, maternal diabetes n=2, cardiac disease n=1). Inherited thrombophilia was also diagnosed in seven out of 35 cases investigated. Twenty three children received supportive treatment: 42 received heparin and in 13 neonates thrombolytic agents were administered. Most neonates (91%) survived; seven died.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Controlled multicentre studies are needed to obtain more information on treatment efficacy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.76.3.f163","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:48:05Z","timestamp":1239191285000},"page":"F163-F167","source":"Crossref","is-referenced-by-count":329,"title":["Neonatal symptomatic thromboembolism in Germany: two year survey"],"prefix":"10.1136","volume":"76","author":[{"given":"Ulrike","family":"Nowak-G\u00f6ttl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"von Kries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ullrich","family":"G\u00f6bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"2025090510113454000_76.3.F163.1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0038-1651110","article-title":"Laboratory screening of inherited thrombotic syndromes.","volume":"57","author":"Mannucci","year":"1987","journal-title":"Thromb Haemostas"},{"key":"2025090510113454000_76.3.F163.2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1055\/s-0038-1642714","article-title":"Developmental hemostasis: Relevance to thromboembolic complications in pediatric patients.","volume":"74","author":"Andrew","year":"1995","journal-title":"Thromb Haemostas"},{"key":"2025090510113454000_76.3.F163.3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1055\/s-2008-1071573","article-title":"Inherited or acquired disorders of blood coagulation in children with neurovascular complications.","volume":"25","author":"G\u00c3\u00b6bel","year":"1994","journal-title":"Neuropediatrics"},{"key":"2025090510113454000_76.3.F163.4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1542\/peds.96.2.291","article-title":"Childhood thrombosis.","volume":"96","author":"Nuss","year":"1995","journal-title":"Pediatrics"},{"key":"2025090510113454000_76.3.F163.5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","article-title":"Neonatal thrombosis: report of a prospective Canadian and international registry.","volume":"96","author":"Schmidt","year":"1995","journal-title":"Pediatrics"},{"key":"2025090510113454000_76.3.F163.6","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(96)00041-2"},{"key":"2025090510113454000_76.3.F163.7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/00007611-196810000-00001","article-title":"Inequality in the size of the lower extremity following cardiac catheterisation.","volume":"61","author":"Bassett","year":"1968","journal-title":"South Med J"},{"key":"2025090510113454000_76.3.F163.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-968X(82)80009-0"},{"key":"2025090510113454000_76.3.F163.9","first-page":"36","article-title":"Neonatal rein vein thrombosis - long term follow up after conservative management.","volume":"17","author":"Jobin","year":"1982","journal-title":"Clin Nephrol"},{"key":"2025090510113454000_76.3.F163.10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0095-5108(18)30929-1","article-title":"Thrombotic disease in newborn infants.","volume":"11","author":"Schmidt","year":"1984","journal-title":"Clin Perinatol"},{"key":"2025090510113454000_76.3.F163.11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000402591","article-title":"Renal venous thrombosis.","volume":"15","author":"Arneil","year":"1979","journal-title":"Contrib Nephrol"},{"key":"2025090510113454000_76.3.F163.12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00043426-199021000-00019","article-title":"Development of the hemostatic system in the neonate and young infant.","volume":"12","author":"Andrew","year":"1990","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"2025090510113454000_76.3.F163.13","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","article-title":"Maturation of the hemostatic system during childhood.","volume":"80","author":"Andrew","year":"1992","journal-title":"Blood"},{"key":"2025090510113454000_76.3.F163.14","doi-asserted-by":"publisher","DOI":"10.1007\/BF02282879"},{"key":"2025090510113454000_76.3.F163.15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.424957.x"},{"key":"2025090510113454000_76.3.F163.16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1055\/s-0038-1649814","article-title":"Diagnosis and treatment of venous thromboembolism in children and adolescents. On behalf of the subcommittee on perinatal haemostasis of the scientific and standardization committee of the ISTH.","volume":"74","author":"David","year":"1995","journal-title":"Thromb Haemostas"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.76.3.F163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:15:20Z","timestamp":1757092520000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.76.3.F163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,1]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1997,5,1]]},"published-print":{"date-parts":[[1997,5,1]]}},"alternative-id":["10.1136\/fn.76.3.F163"],"URL":"https:\/\/doi.org\/10.1136\/fn.76.3.f163","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,1]]}}}