{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:06:45Z","timestamp":1761523605988,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1997,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>To compare the effects of a single dose of frusemide administered either intravenously or by nebulisation on pulmonary mechanics in premature infants with evolving chronic lung disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The effect of frusemide on pulmonary mechanics was studied at a median postnatal age of 23 (range 14\u201352) days in 19 premature infants at 24 to 30 weeks gestational age, who had been dependent on mechanical ventilation since birth. Frusemide (1 mg\/kg\/body weight) was administered, in random order, intravenously and by nebulisation, on two separate occasions 24 hours apart. Pulmonary function studies were performed before and at 30, 60, and 120 minutes after administration of frusemide. Urine was collected for six hours immediately before and for six hours after administration of frusemide.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Nebulised frusemide increased the tidal volume 31(SE 11.5)% and compliance 34 (SE 12)% after two hours, whereas no change in either was noted for up to two hours after intravenous frusemide administration. Neither intravenous nor nebulised frusemide had any effect on airway resistance. Six hour urine output increased from a mean (SE) of 3.3 (0.4) ml\/kg\/hour to 5.9 (0.8) ml\/kg\/hour following intravenous frusemide administration while nebulised frusemide had no effect on urine output. Urinary sodium, potassium, and chloride losses were also significantly higher after intravenous frusemide, whereas nebulised frusemide did not increase urinary electrolyte losses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Single dose nebulised frusemide improves pulmonary function in premature infants with evolving chronic lung disease without adverse effects on fluid and electrolyte balance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.77.1.f32","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:48:05Z","timestamp":1239191285000},"page":"F32-F35","source":"Crossref","is-referenced-by-count":30,"title":["Pulmonary function changes after nebulised and intravenous frusemide in ventilated premature infants"],"prefix":"10.1136","volume":"77","author":[{"given":"Vishwanath G","family":"Prabhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Keszler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramasubbareddy","family":"Dhanireddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1997,7,1]]},"reference":[{"key":"2025090514321495000_77.1.F32.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80382-5"},{"key":"2025090514321495000_77.1.F32.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80728-7"},{"key":"2025090514321495000_77.1.F32.3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0095-5108(18)30739-5","article-title":"Pharmacotherapy in bronchopulmonary dysplasia.","volume":"14","author":"Blanchard","year":"1987","journal-title":"Clin Perinatol"},{"key":"2025090514321495000_77.1.F32.4","first-page":"917","article-title":"Pulmonary and renal responses to furosemide in infants with stage 3-4 BPD.","volume":"139","author":"Patel","year":"1985","journal-title":"Am J Dis Child"},{"key":"2025090514321495000_77.1.F32.5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1542\/peds.74.1.37","article-title":"Effect of oral diuretics on pulmonary mechanics in infants with chronic BPD: results of double blind cross over sequential trial.","volume":"74","author":"Kao","year":"1984","journal-title":"Pediatrics"},{"key":"2025090514321495000_77.1.F32.6","first-page":"141A","article-title":"Lasix improves lung function in infants with chronic lung disease.","volume":"31","author":"McCann","year":"1983","journal-title":"Clin Res"},{"key":"2025090514321495000_77.1.F32.7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1203\/00006450-198104001-01413","article-title":"Pulmonary effects of furosemide in premature infants with lung disease.","volume":"15","author":"Najak","year":"1981","journal-title":"Pediatr Res"},{"key":"2025090514321495000_77.1.F32.8","first-page":"944","article-title":"Inhaled furosemide and asthma [editorial].","volume":"21","year":"1990","journal-title":"Lancet"},{"key":"2025090514321495000_77.1.F32.9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1183\/09031936.93.06010130","article-title":"Inhaled loop diuretics as potential new anti-asthmatic drugs.","volume":"6","author":"Bianco","year":"1993","journal-title":"Eur Respir J"},{"key":"2025090514321495000_77.1.F32.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82018-9"},{"key":"2025090514321495000_77.1.F32.11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ppul.1950040306","article-title":"Evaluation of neonatal pulmonary mechanics and energies; A two factor least mean square analysis.","volume":"4","author":"Bhutani","year":"1988","journal-title":"Pediatr Pulmonol"},{"key":"2025090514321495000_77.1.F32.12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/000992289103000502","article-title":"Urinalysis: Direct versus diaper collection.","volume":"30","author":"Beeram","year":"1991","journal-title":"Clin Pediatr"},{"key":"2025090514321495000_77.1.F32.13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0095-5108(18)31014-5","article-title":"Edema formation in the newborn lung.","volume":"9","author":"Bland","year":"1982","journal-title":"Clin Perinatol"},{"key":"2025090514321495000_77.1.F32.14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0095-5108(18)30446-9","article-title":"Current therapy of bronchopulmonary dysplasia.","volume":"19","author":"Rush","year":"1992","journal-title":"Clin Perinatol"},{"key":"2025090514321495000_77.1.F32.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82458-8"},{"key":"2025090514321495000_77.1.F32.16","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI109608","article-title":"Effect of furosemide in canine low pressure pulmonary edema.","volume":"64","author":"Ali","year":"1979","journal-title":"J Clin Invest"},{"key":"2025090514321495000_77.1.F32.17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/ajrccm\/142.3.576","article-title":"Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects.","volume":"142","author":"Nichol","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"2025090514321495000_77.1.F32.18","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1164\/ajrccm\/143.6.1329","article-title":"Effect of inhaled furosemide and bumetanide on adenosine 5\u2032-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects.","volume":"143","author":"O\u2019Connor","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"2025090514321495000_77.1.F32.19","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1164\/ajrccm\/146.6.1518","article-title":"Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air.","volume":"146","author":"O\u2019Donnell","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2025090514321495000_77.1.F32.20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1164\/ajrccm\/146.2.364","article-title":"Effect of inhaled furosemide and torasemide on bronchial response to ultrasonically nebulized distilled water in asthmatic subjects.","volume":"146","author":"Foresi","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"2025090514321495000_77.1.F32.21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1183\/09031936.93.03060665","article-title":"Inhibition of adenosine 5\u2032-monophosphate and methacholine induced bronchoconstriction in asthma by inhaled furosemide.","volume":"3","author":"Polosa","year":"1990","journal-title":"Eur Respir J"},{"key":"2025090514321495000_77.1.F32.22","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.10.797"},{"key":"2025090514321495000_77.1.F32.23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1056\/NEJM199101103240218","article-title":"Inhibition of furosemide of inflammatory mediators from lung fragments (letter).","volume":"324","author":"Anderson","year":"1991","journal-title":"N Engl J Med"},{"key":"2025090514321495000_77.1.F32.24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1164\/ajrccm\/143.3.561","article-title":"Inhaled furosemide prevents both the bronchoconstriction and the increase in neutrophil chemotactic activity induced by ultrasonic \u2018fog\u2019 of distilled water in asthmatics.","volume":"143","author":"Mosacato","year":"1991","journal-title":"Am Rev Respir Dis"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.77.1.F32","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T21:33:17Z","timestamp":1757107997000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.77.1.F32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7,1]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1997,7,1]]},"published-print":{"date-parts":[[1997,7,1]]}},"alternative-id":["10.1136\/fn.77.1.F32"],"URL":"https:\/\/doi.org\/10.1136\/fn.77.1.f32","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"type":"print","value":"1359-2998"},{"type":"electronic","value":"1468-2052"}],"subject":[],"published":{"date-parts":[[1997,7,1]]}}}