{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:11:53Z","timestamp":1784164313098,"version":"3.55.0"},"reference-count":13,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To evaluate the influence of the intravenous injection of iodine during cardiac catheterisation, and of topical iodine antiseptics during surgical procedures, on thyroid function in full term neonates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Twenty one full term infants with major cardiac anomalies who survived for more than a month were studied. Thyroxine and thyrotropin concentrations were measured (by radioimmunoassay) before each procedure, 24 hours after the procedure, and every week thereafter until the age of 1 month or until normal. Thyroxine values less than 64.4 nmol\/l were considered low, while thyrotropin values greater than 30 mU\/l were considered high.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Thyroid function tests before iodine exposure were within normal limits in all infants. Following catheterisation or surgery six infants had raised thyrotropin concentrations; three had low thyroxine concentrations. Two of those infants were treated with L-thyroxine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Iodine exposure during cardiac catheterisation or surgery may induce transient hypothyroidism in term infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.77.3.f239","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:48:05Z","timestamp":1239191285000},"page":"F239-F240","source":"Crossref","is-referenced-by-count":31,"title":["Iodine and hypothyroidism in neonates with congenital heart disease"],"prefix":"10.1136","volume":"77","author":[{"given":"N","family":"Linder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Sela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"German","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Davidovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kuint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hegesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"2025090511253335000_77.3.F239.1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0025-7125(16)30995-6","article-title":"Effects of iodine containing compounds on thyroid function.","volume":"69","author":"Silva","year":"1985","journal-title":"Med Clin North Am"},{"key":"2025090511253335000_77.3.F239.2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1993.3.119"},{"key":"2025090511253335000_77.3.F239.3","first-page":"13","article-title":"Bestimmung der harnjodansscheidung mittels einer modifizierten Cer-Arsenitmethode.","volume":"8","author":"Wawschinek","year":"1985","journal-title":"Berichte OGKC"},{"key":"2025090511253335000_77.3.F239.4","doi-asserted-by":"publisher","DOI":"10.1159\/000180924"},{"key":"2025090511253335000_77.3.F239.5","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(91)91295-7"},{"key":"2025090511253335000_77.3.F239.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.451615"},{"key":"2025090511253335000_77.3.F239.7","unstructured":"Fisher DA (1991) Thyroid physiology in the perinatal period and during childhood. in The thyroid. eds Braverman LE Utiger RD (JB Lippincott Company, Philadelphia), pp 1207\u20131218."},{"key":"2025090511253335000_77.3.F239.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80028-6"},{"key":"2025090511253335000_77.3.F239.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)81052-4"},{"key":"2025090511253335000_77.3.F239.10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0140-6736(89)90903-3","article-title":"Topical iodine containing antiseptics and neonatal hypothyroidism in very-low birthweight infants.","volume":"ii","author":"Smerdely","year":"1989","journal-title":"Lancet"},{"key":"2025090511253335000_77.3.F239.11","first-page":"795","article-title":"Brief antiseptic application of iodine in neonatal intensive care units; effects on thyroid function.","volume":"1","author":"Vilain","year":"1994","journal-title":"Arch Pediatr"},{"key":"2025090511253335000_77.3.F239.12","first-page":"369","article-title":"Transient disorders of thyroid function and regulation in preterm infants.","volume":"14","author":"Delange","year":"1983","journal-title":"Pediatric and Adolescent Endocrinology."},{"key":"2025090511253335000_77.3.F239.13","doi-asserted-by":"crossref","first-page":"F73","DOI":"10.1136\/fn.71.2.F73","article-title":"Percutaneous drug absorption and administration.","volume":"71","author":"Choonara","year":"1994","journal-title":"Arch Dis Child"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.77.3.F239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T18:49:27Z","timestamp":1757098167000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.77.3.F239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11,1]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1997,11,1]]},"published-print":{"date-parts":[[1997,11,1]]}},"alternative-id":["10.1136\/fn.77.3.F239"],"URL":"https:\/\/doi.org\/10.1136\/fn.77.3.f239","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11,1]]}}}