{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T23:54:13Z","timestamp":1774914853238,"version":"3.50.1"},"reference-count":38,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>To evaluate pulmonary deposition and gas exchange following nebulisation of two surfactants by either a jet or an ultrasonic nebuliser.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHOD<\/jats:title>\n                  <jats:p>After bronchoalveolar lavage (BAL), 19 rabbits were ventilated in four groups. Group A1 (n=5) and A2 (n=6) received Technetium-99m labelled Exosurf, and groups B1 (n=4) and B2 (n=4) received radiolabelled Survanta. Groups A1 and B1 received jet nebuliser therapy, whereas groups A2 and B2 received ultrasonic nebuliser. Pulmonary deposition, distribution, and blood gases were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Pulmonary deposition as per cent of initial dose and mg lipid) was 0.28(0.10)% or 0.59(0.21) mg in group A1, 1.05(0.23)% or 2.21(0.48) mg in group A2, 0.08(0.02)% or 0.30(0.08) mg in group B1, and 0.09(0.02)% or 0.34(0.08) mg in group B2. Deposition in group A2 was greater than in other groups (p= 0.001). Group A2 showed a small improvement in blood gases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Even the highest deposition\u2014ultrasonic nebuliser witosurf\u2014achieved limited clinical effect. The aerosol route is currently not effective for surfactant treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.78.1.f3","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:16Z","timestamp":1239190756000},"page":"F3-F9","source":"Crossref","is-referenced-by-count":44,"title":["Nebulisation of surfactants in an animal model of neonatal respiratory distress"],"prefix":"10.1136","volume":"78","author":[{"given":"Tai 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