{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:40:47Z","timestamp":1759333247005,"version":"3.44.0"},"reference-count":30,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>To evaluate complement and contact activation after fetal acidosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Fifteen term neonates with hypoxic\u2013ischaemic encephalopathy after umbilical arterial pH &lt; 7.10 were compared with 15 healthy neonates with umbilical arterial pH &gt; 7.20. Determinations of the complement function and C1-inhibitor activity were performed as kinetic tests 22\u201328 hours after birth. C1q, C1-inhibitor, and factor B concentrations were determined by radial immunodiffusion and those of C3a, C5a, and factor XIIa by enzyme immunoabsorbent assay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Median complement function (46<jats:italic>vs<\/jats:italic> 73 %), C1q (4.3 <jats:italic>vs<\/jats:italic> 9.1 mg\/dl), and factor B (5.2 <jats:italic>vs<\/jats:italic> 7.7 mg\/dl) decreased after fetal acidosis. The activated split products C3a (260 <jats:italic>vs<\/jats:italic> 185 \u03bcg\/l), C5a (5.0<jats:italic>vs<\/jats:italic> 0.6 \u03bcg\/l), and factor XIIa (3.2 <jats:italic>vs<\/jats:italic> 1.3 \u03bcg\/l) increased in the neonates after fetal acidosis. No differences were found in the concentration and activity of C1-inhibitor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Complement and contact activation occurred in the newborns with hypoxic\u2013ischaemic encephalopathy. Activation of these systems generates mediators which can trigger inflammation and tissue injury.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.78.2.f125","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:16Z","timestamp":1239190756000},"page":"F125-F128","source":"Crossref","is-referenced-by-count":20,"title":["Complement and contact activation in term neonates after fetal acidosis"],"prefix":"10.1136","volume":"78","author":[{"given":"Josef","family":"Sonntag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias 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