{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:15:02Z","timestamp":1781777702821,"version":"3.54.5"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>To evaluate factors predictive of individual response to dexamethasone in preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A cohort of 74 preterm infants born between January 1993 and February 1996 was studied retrospectively. All of them had received dexamethasone to facilitate weaning from artificial ventilation. Demographic factors, ventilation parameters, and details of dexamethasone administration were recorded from the medical and nursing notes. Radiographs were assessed by one observer who was unaware of the clinical condition of the infant or the outcome. Outcome variables examined included change in ventilation index (VI) at 36\u201348 hours, the number of days to extubation from the start of dexamethasone, and death before extubation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Most babies improved but changes in VI at 36\u201348 hours ranged from substantial deterioration to dramatic improvement. No identifiable factors were significantly associated with this range of response. The median time to extubation was 6 days. The 36 babies who extubated within the first 6 days were: significantly more mature; less likely to have pulmonary interstitial emphysema (PIE) or pneumothorax; and had significantly lower VIs in the 12 hours preceding dexamethasone treatment. The postconceptional age at extubation was the same whether babies were extubated within or after the first 6 days. Multiple linear regression confirmed a significant association between number of days to extubation and the three factors described above (adjusted R<jats:sup>2<\/jats:sup>=0.5126).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Individual responses to dexamethasone can be partly predicted by gestation, the presence of PIE, and the VI before dexamethasone administration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.78.3.f199","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:16Z","timestamp":1239190756000},"page":"F199-F203","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of individual response to postnatal dexamethasone in ventilator dependent preterm infants"],"prefix":"10.1136","volume":"78","author":[{"given":"Carl","family":"Kuschel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"2025090510272531000_78.3.F199.1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1542\/peds.75.1.106","article-title":"Controlled trial of dexamethasone in respirator-dependent infants with bronchopulmonary dysplasia.","volume":"75","author":"Avery","year":"1985","journal-title":"Pediatrics"},{"key":"2025090510272531000_78.3.F199.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80754-1"},{"key":"2025090510272531000_78.3.F199.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906083202301"},{"key":"2025090510272531000_78.3.F199.4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1542\/peds.86.5.722","article-title":"Dexamethasone effects on the hospital course of infants with bronchopulmonary dysplasia who are dependent on artificial ventilation.","volume":"86","author":"Kazzi","year":"1990","journal-title":"Pediatrics"},{"key":"2025090510272531000_78.3.F199.5","first-page":"421","article-title":"Dexamethasone therapy in neonatal chronic lung disease: an international placebo-controlled.","volume":"88","year":"1991","journal-title":"Pediatrics"},{"key":"2025090510272531000_78.3.F199.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80547-5"},{"key":"2025090510272531000_78.3.F199.7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1203\/00006450-199407001-00022","article-title":"Two doses of early intravenous dexamethasone for the prevention of bronchopulmonary dysplasia in babies with respiratory distress syndrome.","volume":"36","author":"Sanders","year":"1994","journal-title":"Pediatr Res"},{"key":"2025090510272531000_78.3.F199.8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1542\/peds.95.4.584","article-title":"Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants: a randomized, controlled 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neonates.","volume":"93","author":"Groneck","year":"1994","journal-title":"Pediatrics"},{"key":"2025090510272531000_78.3.F199.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80390-1"},{"key":"2025090510272531000_78.3.F199.18","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1044","article-title":"Effect of dexamethasone on pulmonary inflammation and pulmonary function of ventilator-dependent infants with bronchopulmonary dysplasia.","volume":"143","author":"Yoder","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"2025090510272531000_78.3.F199.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81155-2"},{"key":"2025090510272531000_78.3.F199.20","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0022-3476(09)90024-5","article-title":"Effects of dexamethasone on chemotactic activity and inflammatory mediators in tracheobronchial aspirates of preterm infants at risk for chronic lung 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