{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:21:52Z","timestamp":1773292912746,"version":"3.50.1"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To test the hypothesis that complications of neonatal intensive care are related to increased oxygen derived free radical activity, using breath pentane as a marker of lipid peroxidation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Exhaled breath was collected daily from 57 ventilated preterm infants and pentane concentration measured by gas chromatography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>High peak pentane exhalation was significantly associated with low gestational age, mortality, intraventricular haemorrhage and retinopathy of prematurity. Peak pentane was not significantly associated with the development of chronic lung disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The demonstration that pentane exhalation is related to the course of neonatal disease and its outcome is consistent with the hypothesis that lipid peroxidation is associated with these illnesses, and may contribute to their severity. If this is a causal relation, antioxidant treatments could prove useful in reducing their severity. Measurement of breath pentane might assist in the assessment of antioxidant strategies prior to more extensive clinical trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.79.1.f67","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:16Z","timestamp":1239190756000},"page":"F67-F69","source":"Crossref","is-referenced-by-count":34,"title":["Breath pentane as a marker for lipid peroxidation and adverse outcome in preterm infants"],"prefix":"10.1136","volume":"79","author":[{"given":"J A","family":"Nycyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Drury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W I","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"2025090514313977000_79.1.F67.1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1203\/00006450-198802000-00001","article-title":"Hypoxanthine as an indicator of hypoxia: its role in health and disease through free-radical production.","volume":"23","author":"Saugstadt","year":"1988","journal-title":"Pediatr Res"},{"key":"2025090514313977000_79.1.F67.2","doi-asserted-by":"crossref","first-page":"F107","DOI":"10.1136\/fn.70.2.F107","article-title":"Lipid peroxidation as a measure of oxygen free radical damage in the very low birthweight infant.","volume":"70","author":"Inder","year":"1994","journal-title":"Arch Dis Child"},{"key":"2025090514313977000_79.1.F67.3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1651-2227.1993.tb12639.x","article-title":"Urinary malondialdehyde in preterm neonates; is there a relationship to disease entities of neonatal intensive care?","volume":"82","author":"Schlenzig","year":"1993","journal-title":"Acta Paediatr"},{"key":"2025090514313977000_79.1.F67.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82668-X"},{"key":"2025090514313977000_79.1.F67.5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1203\/00006450-199101000-00011","article-title":"Generation of free radicals in lipid emulsion used in parenteral nutrition.","volume":"29","author":"Pitkanen","year":"1991","journal-title":"Pediatr Res"},{"key":"2025090514313977000_79.1.F67.6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1203\/00006450-199407001-00009","article-title":"Immaturity-dependent free radical activity in premature infants.","volume":"36","author":"Varsila","year":"1994","journal-title":"Pediatr Res"},{"key":"2025090514313977000_79.1.F67.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00480-7"},{"key":"2025090514313977000_79.1.F67.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"2025090514313977000_79.1.F67.9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1542\/peds.74.1.127","article-title":"International classification of ROP.","volume":"74","year":"1984","journal-title":"Pediatrics"},{"key":"2025090514313977000_79.1.F67.10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.1_Spec_No.44"},{"key":"2025090514313977000_79.1.F67.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6385.81"},{"key":"2025090514313977000_79.1.F67.12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-3476(87)80086-0","article-title":"Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia.","volume":"111","author":"Shenai","year":"1987","journal-title":"J Pediatr"},{"key":"2025090514313977000_79.1.F67.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80307-8"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.79.1.F67","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T21:32:31Z","timestamp":1757107951000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.79.1.F67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1998,7,1]]},"published-print":{"date-parts":[[1998,7,1]]}},"alternative-id":["10.1136\/fn.79.1.F67"],"URL":"https:\/\/doi.org\/10.1136\/fn.79.1.f67","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7,1]]}}}