{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:28:02Z","timestamp":1791199682695,"version":"4.2.0"},"reference-count":22,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To determine the influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia on transplacental IgG antibody transfer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>One hundred and eighty materno-neonatal pairs from a Malawian population were assessed. Cord and maternal serum samples were tested for total serum IgG antibody titres using nephelometry, and for specific IgG antibody titres to<jats:italic>Streptococcus pneumoniae<\/jats:italic>, measles, and tetanus toxoid antibodies using an enzyme linked immunsorbent assay (ELISA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Multiple regression analyses showed that placental malaria was associated with a decrease in placental IgG antibody transfer to <jats:italic>S pneumoniae<\/jats:italic> and measles to 82% and 81%, respectively. Maternal HIV infection was associated with a reduction in IgG antibody transfer to <jats:italic>S pneumoniae<\/jats:italic> to 79%; raised maternal total serum IgG titres were correlated with<jats:italic>S pneumoniae<\/jats:italic> and measles IgG antibody transfer reduction to 86% and 87%, respectively. No effect was seen with tetanus toxoid antibody transfer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>The combined influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia seems to be linked to the low transplacental antibody transfer observed in the Malawian population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.79.3.f202","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:16Z","timestamp":1239190756000},"page":"F202-F205","source":"Crossref","is-referenced-by-count":157,"title":["Placental antibody transfer: influence of maternal HIV infection and placental malaria"],"prefix":"10.1136","volume":"79","author":[{"given":"M Isabel","family":"de Moraes-Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Verhoeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyson","family":"Chimsuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J M","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalanga","family":"Wesumperuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L","family":"Broadhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J","family":"Brabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Anthony","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"2025090510062546000_79.3.F202.1","first-page":"317","article-title":"Transplacental antibody transfer and neonatal immunity.","volume":"58","author":"de Moraes-Pinto","year":"1997","journal-title":"Br J Hosp Med"},{"key":"2025090510062546000_79.3.F202.2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1056\/NEJM196107272650403","article-title":"Living attenuated measles-virus vaccine in early infancy. 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