{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:56:40Z","timestamp":1757617000634,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To attempt to define the prevalence and significance of murmurs detected on routine clinical examination at six to eight weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A retrospective review of the results of routine clinical examination of a cohort of 6 to 8 week old babies resident in Newcastle upon Tyne, was carried out in two 12 month periods. All cardiac defects diagnosed in infancy in the same cohort were ascertained.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>7132 babies were eligible for routine examination; 83% of these were examined. Murmurs were heard in 47 of 5395 babies and in 11 of 25 referred for evaluation congenital heart disease was found. The six to eight week examination led to diagnosis of 11 of 35 cases (31%) of congenital heart disease in the study population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Nearly one baby in 100 had a murmur on routine examination at six to eight weeks. Nearly half of those with murmurs who were referred had a structural cardiovascular malformation.<\/jats:p>\n                  <jats:p>\n                     <jats:boxed-text position=\"float\">\n                        <jats:sec>\n                           <jats:title>Key messages<\/jats:title>\n                           <jats:list list-type=\"simple\">\n                              <jats:list-item>\n                                 <jats:p>Only 83% of eligible babies received routine examination for signs of heart disease and only 56% between 6 and 8 weeks of age.<\/jats:p>\n                              <\/jats:list-item>\n                              <jats:list-item>\n                                 <jats:p>Murmurs were heard in roughly one baby in 100 (0.9%).<\/jats:p>\n                              <\/jats:list-item>\n                              <jats:list-item>\n                                 <jats:p>About one quarter of babies with murmurs had structural heart disease but only about half were referred.<\/jats:p>\n                              <\/jats:list-item>\n                              <jats:list-item>\n                                 <jats:p>Referral of all babies with murmurs at this age for expert evaluation is recommended.<\/jats:p>\n                              <\/jats:list-item>\n                           <\/jats:list>\n                        <\/jats:sec>\n                     <\/jats:boxed-text>\n                  <\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.80.1.f46","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:47Z","timestamp":1239190787000},"page":"F46-F48","source":"Crossref","is-referenced-by-count":17,"title":["Examination for cardiac malformations at six weeks of age"],"prefix":"10.1136","volume":"80","author":[{"given":"Jill","family":"Gregory","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Emslie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Wyllie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Wren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"2025090514332254000_80.1.F46.1","unstructured":"Hall DMB , ed (1996) Health for all children. Report of the third joint working party on child health surveillance. (Oxford University Press, Oxford)."},{"key":"2025090514332254000_80.1.F46.2","doi-asserted-by":"crossref","first-page":"F770","DOI":"10.1136\/adc.67.7_Spec_No.770","article-title":"Fetal abnormality, an audit of its recognition and management.","volume":"67","year":"1992","journal-title":"Arch Dis Child"},{"key":"2025090514332254000_80.1.F46.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6432.1717"},{"key":"2025090514332254000_80.1.F46.4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/01.CIR.43.3.323","article-title":"Congenital heart disease in 56,109 births.","volume":"43","author":"Mitchell","year":"1971","journal-title":"Circulation"},{"key":"2025090514332254000_80.1.F46.5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.1.93"},{"key":"2025090514332254000_80.1.F46.6","doi-asserted-by":"crossref","first-page":"F49","DOI":"10.1136\/fn.80.1.F49","article-title":"Presentation of congenital heart disease in infancy: implications for routine examination.","volume":"80","author":"Wren","year":"1999","journal-title":"Arch Dis Child"},{"key":"2025090514332254000_80.1.F46.7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02083294"},{"key":"2025090514332254000_80.1.F46.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00801907"},{"key":"2025090514332254000_80.1.F46.9","doi-asserted-by":"crossref","first-page":"F71","DOI":"10.1136\/fn.70.1.F71","article-title":"Assessment and management of congenital heart disease in the newborn by the district paediatrician.","volume":"70","author":"Silove","year":"1994","journal-title":"Arch Dis Child"},{"key":"2025090514332254000_80.1.F46.10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/oxfordjournals.aje.a113979","article-title":"Congenital heart disease: prevalence at live birth.","volume":"121","author":"Ferencz","year":"1985","journal-title":"Am J Epidemiol"},{"key":"2025090514332254000_80.1.F46.11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/oxfordjournals.aje.a114978","article-title":"Congenital heart disease: incidence in the first year of life.","volume":"128","author":"Grabitz","year":"1988","journal-title":"Am J Epidemiol"},{"key":"2025090514332254000_80.1.F46.12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1440-1754.1993.tb00531.x","article-title":"The incidence of congenital heart defects in the first year of life.","volume":"29","author":"Kidd","year":"1993","journal-title":"J Paediatr Child Health"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.80.1.F46","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T21:33:54Z","timestamp":1757108034000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.80.1.F46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,1]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,1,1]]},"published-print":{"date-parts":[[1999,1,1]]}},"alternative-id":["10.1136\/fn.80.1.F46"],"URL":"https:\/\/doi.org\/10.1136\/fn.80.1.f46","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"type":"print","value":"1359-2998"},{"type":"electronic","value":"1468-2052"}],"subject":[],"published":{"date-parts":[[1999,1,1]]}}}