{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:23:13Z","timestamp":1791037393941,"version":"4.1.0"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"\n AIM<\/jats:title>\n To determine whether pancreatitis associated protein (PAP) is a marker for cystic fibrosis which could be used in neonatal screening for the disease.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n PAP was assayed on screening cards from 202 807 neonates. Babies with PAP \u2a7e 15 ng\/ml, or \u2a7e 11.5 ng\/ml and immunoreactive trypsinogen (IRT) \u2a7e 700 ng\/ml were recalled for clinical examination, sweat testing, and cystic fibrosis transmembrane regulator (CFTR) gene analysis.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Median PAP value was 2.8 ng\/ml. Forty four cases of cystic fibrosis were recorded. Recalled neonates (n=398) included only 11 carriers. A receiver operating characteristic curve analysis showed that PAP above 8.0 ng\/ml would select 0.76% of babies, including all those with cystic fibrosis, except for one with meconium ileus and two with mild CFTR mutations. Screening 27 146 babies with both PAP and IRT showed that only 0.12% had PAP > 8.0 ng\/ml and IRT > 700 ng\/ml, including all cases of cystic fibrosis.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n PAP is increased in most neonates with cystic fibrosis and could be used for CF screening. Its combination with IRT looks promising.<\/jats:p>\n \n \n \n Key messages<\/jats:title>\n \n \n CF neonatal screening with PAP is technically feasible in the same environment as other neonatal screenings (PKU, hypothyroidism)<\/jats:p>\n <\/jats:list-item>\n \n CF neonatal screening with PAP alone performs similarly to screening with IRT alone, with less carrier detection<\/jats:p>\n <\/jats:list-item>\n \n Combining PAP with IRT for CF neonatal screening could be as efficient as the IRT\/DNA strategy, but would be cheaper and incur limited carrier detection<\/jats:p>\n <\/jats:list-item>\n \n If a legal requirement for informed consent before DNA testing has expired, the PAP\/IRT strategy would be an alternative to the IRT\/DNA strategy<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/fn.80.2.f118","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:47Z","timestamp":1239190787000},"page":"F118-F122","source":"Crossref","is-referenced-by-count":35,"title":["Blood concentrations of pancreatitis associated protein in neonates: relevance to neonatal screening for cystic fibrosis"],"prefix":"10.1136","volume":"80","author":[{"given":"Jacques","family":"Sarles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Barthellemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"F\u00e9rec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Iovanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Roussey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Farriaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Toutain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Berthelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Maurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Codet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Berth\u00e9z\u00e8ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Dagorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,3,1]]},"reference":[{"key":"2025090510473892000_80.2.F118.1","unstructured":"Welsh MJ Tsui LC Boat TF Beaudet AL (1995) Cystic Fibrosis. in The Metabolic and Molecular Bases of Inherited Diseases. eds Scriver CF Beaudet AL Sly WS (MacGraw-Hill, New York), pp 3799\u00e2\u0080\u00933876."},{"key":"2025090510473892000_80.2.F118.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2570460"},{"key":"2025090510473892000_80.2.F118.3","doi-asserted-by":"publisher","DOI":"10.1016\/0925-6164(93)90017-D"},{"key":"2025090510473892000_80.2.F118.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371403"},{"key":"2025090510473892000_80.2.F118.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371409"},{"key":"2025090510473892000_80.2.F118.6","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0140-6736(79)90825-0","article-title":"Dried blood spot screening for cystic fibrosis in the newborn.","volume":"ii","author":"Crossley","year":"1979","journal-title":"Lancet"},{"key":"2025090510473892000_80.2.F118.7","first-page":"71","article-title":"Le d\u00c3\u00a9pistage n\u00c3\u00a9onatal de la mucoviscidose. Enjeux et r\u00c3\u00a9sultats du programme fran\u00c3\u00a7ais d\u00e2\u0080\u0099\u00c3\u00a9valuation.","volume":"33","author":"Farriaux","year":"1992","journal-title":"J Immunol Anal Biol Spec"},{"key":"2025090510473892000_80.2.F118.8","first-page":"288","article-title":"Prenatal diagnosis in 200 pregnancies with 1-in-4 risk of cystic fibrosis.","volume":"74","author":"Bou\u00c3\u00a9","year":"1986","journal-title":"Hum Genet"},{"key":"2025090510473892000_80.2.F118.9","doi-asserted-by":"publisher","DOI":"10.1016\/0885-4505(91)90055-P"},{"key":"2025090510473892000_80.2.F118.10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.6.819"},{"key":"2025090510473892000_80.2.F118.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70040-4"},{"key":"2025090510473892000_80.2.F118.12","first-page":"354","article-title":"Worldwide survey of the delta F508 mutation. Report from the Cystic Fibrosis Genetic Analysis Consortium.","volume":"47","year":"1990","journal-title":"Am J Hum Genet"},{"key":"2025090510473892000_80.2.F118.13","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/0016-5085(94)90708-0","article-title":"Serum levels of pancreatitis-associated protein as indicators of the course of acute pancreatitis.","volume":"106","author":"Iovanna","year":"1994","journal-title":"Gastroenterology"},{"key":"2025090510473892000_80.2.F118.14","first-page":"561","article-title":"The Pancreatitis-Associated Protein (PAP) A new candidate for neonatal screening of cystic fibrosis","volume":"317","author":"Iovanna","year":"1994","journal-title":"C R Acad Sci"},{"key":"2025090510473892000_80.2.F118.15","first-page":"109","article-title":"Donn\u00c3\u00a9es \u00c3\u00a9pid\u00c3\u00a9miologiques. D\u00c3\u00a9pistage n\u00c3\u00a9o- et ant\u00c3\u00a9natal de la mucoviscidose.","volume":"51","author":"Farriaux","year":"1995","journal-title":"Rev Pulm Clin"},{"key":"2025090510473892000_80.2.F118.16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/hmg\/2.1.51","article-title":"Identification of 12 novel mutations in the CFTR gene.","volume":"1","author":"Audr\u00c3\u00a9zet","year":"1993","journal-title":"Hum Mol Genet"},{"key":"2025090510473892000_80.2.F118.17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/clinchem\/27.9.1569","article-title":"Use of receiver operating characteristic curves to evaluate the clinical performances of analytical systems.","volume":"27","author":"Robertson","year":"1981","journal-title":"Clin Chem"},{"key":"2025090510473892000_80.2.F118.18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.10.1557"},{"key":"2025090510473892000_80.2.F118.19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1440-1754.1995.tb00778.x","article-title":"Delayed diagnosis of cystic fibrosis in children with a rare genotype (\u00ce\u0094F508\/R117H).","volume":"31","author":"Fitzgerald","year":"1995","journal-title":"J Pediatr Child Health"},{"key":"2025090510473892000_80.2.F118.20","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/00006676-199409000-00011","article-title":"Rat pancreatitis-associated protein is expressed in relation to the severity of experimental pancreatitis.","volume":"9","author":"Keim","year":"1994","journal-title":"Pancreas"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.80.2.F118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T18:11:31Z","timestamp":1757095891000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.80.2.F118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,3,1]]},"published-print":{"date-parts":[[1999,3,1]]}},"alternative-id":["10.1136\/fn.80.2.F118"],"URL":"https:\/\/doi.org\/10.1136\/fn.80.2.f118","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3,1]]}}}