{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:25:38Z","timestamp":1779924338246,"version":"3.53.1"},"reference-count":35,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To investigate the therapeutic efficacy of inhaled fluticasone propionate, started on day 1 of age, on ventilated preterm infants with respiratory distress syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Starting within 24 hours of age, ventilated preterm infants (gestation &lt; 32 weeks, birthweight &lt; 1.5 kg) with respiratory distress syndrome were given a 14 day course (two puffs, 12 hourly) of either fluticasone propionate (250 \u03bcg\/puff) (group 1, n=27) or placebo (group 2, n=26) with a metered dose inhaler\u2013spacer device. Response to treatment was assessed by the rate of successful extubation by days 7 and 14 of age, changes in respiratory system mechanics, death, occurrence of chronic lung disease, and other neonatal complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>More infants in the treatment group were successfully extubated by 14 days of age than those in the placebo group (17\/27 <jats:italic>vs<\/jats:italic>8\/26; p = 0.038). The treated infants also showed a more significant improvement in respiratory system compliance during the first 14 days of life. The two groups, however, did not differ significantly in their need for systemic steroids after day 14 of age, death, or the occurrence of chronic lung disease. The treatment was not associated with any increase in neonatal complications, including those attributable to steroid induced side effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>These results provide preliminary evidence that early treatment with inhaled corticosteroids may be beneficial to ventilated preterm infants with respiratory distress. Further study of its use in a large scale randomised trial is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.80.3.f203","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:47Z","timestamp":1239190787000},"page":"F203-F208","source":"Crossref","is-referenced-by-count":51,"title":["Randomised controlled study of early use of inhaled corticosteroid in preterm infants with respiratory distress syndrome"],"prefix":"10.1136","volume":"80","author":[{"given":"T F","family":"Fok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dolovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K W","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"2025090514401376000_80.3.F203.1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1172\/JCI111015","article-title":"Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirate during respiratroy distress syndrome.","volume":"72","author":"Merritt","year":"1983","journal-title":"J Clin Invest"},{"key":"2025090514401376000_80.3.F203.2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.1.44"},{"key":"2025090514401376000_80.3.F203.3","first-page":"273","article-title":"Early postnatal dexamethasone therapy in premature infants with severe respiratory distress syndrome: a double blind controlled study.","volume":"117","author":"Yeh","year":"1990","journal-title":"Pediatrics"},{"key":"2025090514401376000_80.3.F203.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.4.e3"},{"key":"2025090514401376000_80.3.F203.5","doi-asserted-by":"crossref","first-page":"F33","DOI":"10.1136\/fn.74.1.F33","article-title":"Failure of early postnatal dexamethasone to prevent chronic lung disease in infants with respiratory distress syndrome.","volume":"74","author":"Shinwell","year":"1996","journal-title":"Arch Dis Child"},{"key":"2025090514401376000_80.3.F203.6","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1542\/peds.101.5.e7","article-title":"Early dexamethasone therapy in preterm infants: a follow-up study.","volume":"101","author":"Yeh","year":"1998","journal-title":"Pediatrics"},{"key":"2025090514401376000_80.3.F203.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381604"},{"key":"2025090514401376000_80.3.F203.8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0022-3476(06)80134-4","article-title":"Controlled trial of beclomethasone dipropionate by nebulization in oxygen- and ventilator-dependent infants.","volume":"122","author":"LaForce","year":"1993","journal-title":"J Pediatr"},{"key":"2025090514401376000_80.3.F203.9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ppul.1950150208","article-title":"Nebulized steroid therapy in bronchopulmonary dysplasia.","volume":"15","author":"Cloutier","year":"1993","journal-title":"Pediatr Pulmonol"},{"key":"2025090514401376000_80.3.F203.10","unstructured":"Dunn M Magnani L Anaka R Kirpalani H (1991) Nebulized steroids for bronchopulmonary dysplasia (BPD) - a randomized, double-blind cross-over study. 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