{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:08:19Z","timestamp":1759565299612,"version":"3.44.0"},"reference-count":36,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To quantify the level of risk for stillbirth and infant death in singleton compared with twin pregnancies, using national data; to determine the independent effects of zygosity, sex, and birthweight on these risks in twin pregnancies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A retrospective national study was carried out of all singleton and twin birth and death registrations in England and Wales 1982\u201391, according to sex and birthweight group. Weinberg\u2019s rule was applied to the twin pairs to differentiate mono- from dizygotic twins. Relative risks for mono- compared with dizygous twins for both twins being stillbirths and for one of the pair being a stillbirth were determined. For twins where one was stillborn and the other live born, the relative risk of neonatal and infant mortality in the surviving co-twin was determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There were 6 563 834 registered singletons and 70772 registered twin pairs for the period under study. Monozygotic twins had a relative risk of: 18.91 (95% CI 12.48\u201328.64) for both twins being stillborn; 1.63 (95% CI 1.48\u20131.79) for one twin being a stillbirth; and 2.26 (95% CI 1.45\u20133.52) for the live born co-twin dying as a neonate. When both twins were live born and among singletons, the odds ratio for neonatal mortality of being male was 1.41 (95% CI 1.37\u20131.45) and there was a highly significant negative association with birthweight. After adjusting for birthweight group and sex, twins had a reduced neonatal mortality compared with singletons: odds ratio 0.91 (95% CI 0.85\u20130.96).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Fetal death in one of monozygotic twins has serious implications for survival of the co-twin. Monochorionicity is probably the essential feature of the increased risk to the co-twin. It is imperative that all fetal deaths in multiple pregnancies are recorded and chorionicity determined if parents are to be adequately counselled.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.80.3.f217","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:47Z","timestamp":1239190787000},"page":"F217-F220","source":"Crossref","is-referenced-by-count":33,"title":["Fetal and infant death in mono- and dizygotic twins in England and Wales 1982\u201391"],"prefix":"10.1136","volume":"80","author":[{"given":"C R","family":"West","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Adi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P O D","family":"Pharoah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"2025090510130476000_80.3.F217.1","first-page":"347","article-title":"The Northwestern University multihospital twin study. 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Problems and outcome with conservative management.","volume":"97","author":"Fusi","year":"1990","journal-title":"Br J Obstet Gynaecol"},{"key":"2025090510130476000_80.3.F217.15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0028-2243(91)90210-C","article-title":"Antenatal fetal death in twin pregnancies: a dangerous condition mainly for the surviving co-twin: a report of four cases.","volume":"38","author":"Van den Veyver","year":"1990","journal-title":"Eur J Obstet Gynaecol"},{"key":"2025090510130476000_80.3.F217.16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/pd.1970100806","article-title":"Central system damage and other anomalies in surviving fetus following second trimester antenatal death of a cotwin. 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