{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:14:48Z","timestamp":1781644488091,"version":"3.54.5"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To assess the cell mediated immune response to BCG vaccine in preterm babies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Sixty two consecutive preterm babies born at &lt; 35 weeks of gestation were randomly allocated into two groups. Babies in group A were vaccinated early at 34\u201335 weeks and group B were vaccinated late at 38\u201340 weeks of postconceptional age. The two groups were similar in terms of: gestational age (mean (SD) 33.1 (1.1) and 33 (1.2) weeks, respectively); birthweight 1583 (204) and 1546 (218) g; neonatal problems; socioeconomic status; and postnatal weight gain. The cell mediated immune response to BCG was assessed using the Mantoux test and the lymphocyte migration inhibition test (LMIT) 6\u20138 weeks after BCG vaccination. Induration of &gt;5 mm after the Mantoux test was taken as a positive response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There was no significant difference in the tuberculin conversion rates (80% and 80.7%, respectively), positive LMIT (86.6% and 90.3%, respectively), or BCG scar (90.0% and 87.1%, respectively) among the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Prematurity seems to be an unlikely cause for poor vaccine uptake. Preterm babies can be effectively vaccinated with BCG at 34\u201335 weeks of postconceptional age, the normal time of discharge in a developing country.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.81.1.f64","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T11:39:47Z","timestamp":1239190787000},"page":"F64-F66","source":"Crossref","is-referenced-by-count":28,"title":["Safety and effectiveness of BCG vaccination in preterm babies"],"prefix":"10.1136","volume":"81","author":[{"given":"Sudhin","family":"Thayyil-Sudhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meharban","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Kumar","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Deorari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"2025090513311366000_81.1.F64.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.4.473"},{"key":"2025090513311366000_81.1.F64.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510330076038"},{"key":"2025090513311366000_81.1.F64.3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.2.144"},{"key":"2025090513311366000_81.1.F64.4","first-page":"69","article-title":"Effectiveness of BCG vaccination against tuberculous meningitis: a case-control study in Soa Paulo, Brazil.","volume":"68","author":"Filho","year":"1990","journal-title":"Bull WHO"},{"key":"2025090513311366000_81.1.F64.5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/02724936.1998.11747967","article-title":"Is zero dose oral polio vaccine effective in preterm babies?","volume":"18","author":"Thayyil-Sudhan","year":"1998","journal-title":"Ann Trop Paediatr"},{"key":"2025090513311366000_81.1.F64.6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1651-2227.1985.tb11030.x","article-title":"Tuberculin conversion following BCG vaccination in preterm infants.","volume":"74","author":"Dawadu","year":"1985","journal-title":"Acta Pediatr Scand"},{"key":"2025090513311366000_81.1.F64.7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.3_Spec_No.309"},{"key":"2025090513311366000_81.1.F64.8","first-page":"679","article-title":"Bacille Calmette Guerin vaccination in preterm infants.","volume":"2","author":"Sedaghatian","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"2025090513311366000_81.1.F64.9","first-page":"173","article-title":"Immune status and BCG vaccination in new-born infants with IUGR.","volume":"26","author":"Singh","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"2025090513311366000_81.1.F64.10","first-page":"508","article-title":"Cell mediated immune response after BCG vaccination as a determinant of optimum age of vaccination.","volume":"65","author":"Kathipari","year":"1982","journal-title":"Indian J Med Res"},{"key":"2025090513311366000_81.1.F64.11","first-page":"899","article-title":"Cell mediated immune response in BCG vaccinated children","volume":"30","author":"Vijayalakshmi","year":"1993","journal-title":"Indian Pediatr"},{"key":"2025090513311366000_81.1.F64.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8479(96)90123-9"},{"key":"2025090513311366000_81.1.F64.13","first-page":"41","article-title":"BCG vaccination of Full-term infants with IUGR:Influence of immunisation age on the development of post vaccination delayed tuberculin sensitivity.","volume":"31","author":"Pinhata","year":"1993","journal-title":"Bull WHO"},{"key":"2025090513311366000_81.1.F64.14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1164\/ajrccm.154.1.8680692","article-title":"Does the protective effect of neonatal BCG vaccination correlate with vaccine-induced tuberculin reactions","volume":"154","author":"Comstock","year":"1996","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.81.1.F64","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:31:22Z","timestamp":1757104282000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.81.1.F64"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,7,1]]},"published-print":{"date-parts":[[1999,7,1]]}},"alternative-id":["10.1136\/fn.81.1.F64"],"URL":"https:\/\/doi.org\/10.1136\/fn.81.1.f64","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7,1]]}}}