{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:48:10Z","timestamp":1769640490756,"version":"3.49.0"},"reference-count":17,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,3,27]]},"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To examine the cardiovascular effects of an intravenous bolus of morphine, 100 \u03bcg\/kg, in 17 ventilated preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Heart rate and blood pressure were monitored. Right ventricular output, superior vena caval flow, and the width of the ductus arteriosus were measured by Doppler echocardiography 10 and 60 minutes after the morphine injection, and the values compared with baseline values by the paired<jats:italic>t<\/jats:italic> test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There was a small but significant fall in heart rate (2.1% at 10 minutes, 4.3% at 60 minutes) consistent with a sedative effect. There was no effect on systolic, diastolic, or mean blood pressure. There was no significant effect on systemic blood flow as measured by either right ventricular output or superior vena caval flow. Ductal width was significantly reduced by a mean of 16% at 60 minutes, suggesting that normal duct closure was not inhibited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>No cardiovascular effects of an intravenous bolus of morphine could be detected.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.83.2.f101","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F101-F103","source":"Crossref","is-referenced-by-count":9,"title":["Cardiovascular effects of an intravenous bolus of morphine in the ventilated preterm infant"],"prefix":"10.1136","volume":"83","author":[{"given":"N","family":"Rutter","sequence":"first","affiliation":[{"name":"aDivision of Child Health, School of Human Development, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK, \n\nbDepartment of Neonatal Medicine, University of Sydney, Royal Prince Alfred Hospital, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Evans","sequence":"additional","affiliation":[{"name":"aDivision of Child Health, School of Human Development, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK, \n\nbDepartment of Neonatal Medicine, University of Sydney, Royal Prince Alfred Hospital, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2025090514081367000_83.2.F101.1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91472-X"},{"key":"2025090514081367000_83.2.F101.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(96)01781-1"},{"key":"2025090514081367000_83.2.F101.3","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1136\/fn.79.1.F34","article-title":"Randomised double blind trial of morphine versus diamorphine for sedation of preterm neonates.","volume":"79","author":"Wood","year":"1998","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090514081367000_83.2.F101.4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.10_Spec_No.1155"},{"key":"2025090514081367000_83.2.F101.5","doi-asserted-by":"publisher","DOI":"10.1136\/fn.73.1.F22"},{"key":"2025090514081367000_83.2.F101.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70114-2"},{"key":"2025090514081367000_83.2.F101.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70078-8"},{"key":"2025090514081367000_83.2.F101.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90363-8"},{"key":"2025090514081367000_83.2.F101.9","doi-asserted-by":"publisher","DOI":"10.1136\/fn.74.2.F88"},{"key":"2025090514081367000_83.2.F101.10","doi-asserted-by":"crossref","first-page":"F182","DOI":"10.1136\/fn.82.3.F182","article-title":"Superior vena cava flow in newborn infants: a novel marker of systemic blood flow.","volume":"82","author":"Kluckow","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090514081367000_83.2.F101.11","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1172\/JCI107869","article-title":"The cardiovascular effects of morphine.","volume":"54","author":"Zelis","year":"1974","journal-title":"J Clin Invest"},{"key":"2025090514081367000_83.2.F101.12","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-194601000-00007"},{"key":"2025090514081367000_83.2.F101.13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/cs0660625","article-title":"Opioid peptides in blood pressure regulation in man.","volume":"66","author":"Rubin","year":"1984","journal-title":"Clin Sci"},{"key":"2025090514081367000_83.2.F101.14","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.27.6.863"},{"key":"2025090514081367000_83.2.F101.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196912182812503"},{"key":"2025090514081367000_83.2.F101.16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.3.236"},{"key":"2025090514081367000_83.2.F101.17","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.3.F156"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.83.2.F101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T21:08:51Z","timestamp":1757106531000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.83.2.F101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,1]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2000,9,1]]},"published-print":{"date-parts":[[2000,9,1]]}},"alternative-id":["10.1136\/fn.83.2.F101"],"URL":"https:\/\/doi.org\/10.1136\/fn.83.2.f101","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,1]]}}}