{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:45:41Z","timestamp":1757616341334,"version":"3.44.0"},"reference-count":32,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,3,27]]},"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To examine in vitro the effects of brief contact with various infusion solutions on red blood cells from newborn infants, as occurs in the \u201cwaste\u201d syringe during routine blood sampling from umbilical artery catheters. The mixture of blood and solution in the \u201cwaste\u201d syringe is usually reinfused into the baby. Reinfused red blood cells may be damaged by the infusion solution. It is hypothesised that an isotonic amino acid solution would cause no red blood cell agglutination and no more haemolysis than many commonly used solutions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Blood was obtained from the placentas of 15 normal term babies. Haemolysis was estimated by measuring plasma (free) haemoglobin after mock blood sampling. Agglutination was measured semiquantitatively by direct observation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A 0.25% normal saline solution caused 5.4% haemolysis, significantly more than all the other fluids tested. There was less haemolysis with 0.25% normal saline when there was complete mixing of blood and solution within the \u201cwaste\u201d syringe. Normal saline and isotonic sodium acetate solutions caused &lt;\u20090.1% haemolysis, significantly less than all the other fluids tested. The isotonic amino acid solution caused 0.8% haemolysis, which is similar to that caused by the remaining solutions tested. Agglutination was seen with isotonic dextrose and with the two isotonic amino acid solutions containing cysteine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Isotonic amino acid solution (without added cysteine) caused no agglutination and the same or less haemolysis than many commonly used solutions and may offer advantages in nutrition and fluid balance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.83.2.f130","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F130-F134","source":"Crossref","is-referenced-by-count":13,"title":["Effects of various arterial infusion solutions on red blood cells in the newborn"],"prefix":"10.1136","volume":"83","author":[{"given":"Jodi K","family":"Jackson","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas P","family":"Derleth","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2025090510363109000_83.2.F130.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994564"},{"key":"2025090510363109000_83.2.F130.2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-999515","article-title":"Medication administration via the umbilical arterial catheter: a survey of standard practices and review of the literature.","volume":"7","author":"Hodding","year":"1990","journal-title":"Am J Perinatol"},{"key":"2025090510363109000_83.2.F130.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80611-0"},{"key":"2025090510363109000_83.2.F130.4","first-page":"484","article-title":"Phases of fluid and electrolyte homeostasis in the extremely low birth weight infant.","volume":"96","author":"Lorenz","year":"1995","journal-title":"Pediatrics"},{"key":"2025090510363109000_83.2.F130.5","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(89)90129-0"},{"key":"2025090510363109000_83.2.F130.6","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.15.2.161"},{"key":"2025090510363109000_83.2.F130.7","first-page":"1","article-title":"Incompatible intravenous fluids: their potential effect on blood and blood transfusion.","volume":"31","author":"Weisz-Carrington","year":"1988","journal-title":"Immunohematology"},{"key":"2025090510363109000_83.2.F130.8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1537-2995.1975.15375160360.x","article-title":"Compatibility of common intravenous solutions with CPD blood.","volume":"15","author":"Ryden","year":"1975","journal-title":"Transfusion"},{"key":"2025090510363109000_83.2.F130.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0372-1248(64)80025-4"},{"key":"2025090510363109000_83.2.F130.10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1537-2995.1985.25185116517.x","article-title":"Hemolysis of donor red cells in \u201ctwo thirds-one third\u201d solution.","volume":"25","author":"Easton","year":"1985","journal-title":"Transfusion"},{"key":"2025090510363109000_83.2.F130.11","doi-asserted-by":"publisher","DOI":"10.1021\/js970184o"},{"key":"2025090510363109000_83.2.F130.12","first-page":"223","article-title":"Lysis of human red blood cells. 1. 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