{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:24:02Z","timestamp":1776468242111,"version":"3.51.2"},"reference-count":13,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,1,6]]},"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine the incidence, complications, management, and outcome in infants with twin-twin transfusion syndrome (TTTS) over a period of five years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>TTTS was diagnosed in monochorionic twins if one was pale and the other plethoric with a haemoglobin difference \u2a7e\u20095 g\/100 ml and\/or birthweight differences \u2a7e\u200915%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Eighteen (6.2%) of the 292 twin pairs had TTTS. Eight pairs (44%) had the acute type and the rest (56%) had the chronic type of TTTS. The mean (SEM) intrapair haemoglobin difference in the acute type was 4.8 (2.1) g\/100 ml which gave a discordance of 7.1 (4.6)%, whereas that in the chronic type was 6.9 (2.9) g\/100 ml and 24.4 (6.1)% respectively. Infants with the acute type had a significantly higher incidence of vaginal delivery (p\u2009&lt;\u20090.03), hypotension (p\u2009&lt;\u20090.025), and respiratory distress (p\u2009&lt;\u20090.01) compared with those with the chronic type. There was no significant difference in the incidence of anaemia, polycythaemia, asphyxia, hypoglycaemia, and hyperbilirubinaemia. Two recipients died in utero as the result of chronic TTTS, while their survivors developed spastic cerebral palsy. There were no neonatal deaths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>TTTS, although uncommon, may have an adverse neurodevelopmental outcome especially if one twin dies in utero. Prompt recognition and management of the haemodynamic and haematological problems of infants with the acute types of TTTS will result in optimal neurodevelopmental outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.83.3.f168","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F168-F170","source":"Crossref","is-referenced-by-count":40,"title":["Twin-twin transfusion syndrome: a five year review"],"prefix":"10.1136","volume":"83","author":[{"given":"Y C","family":"Seng","sequence":"first","affiliation":[{"name":"aDepartment of Pediatrics, Kandang Kerbau Women's and Children's Hospital, Singapore, \n\nbDepartment of Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V S","family":"Rajadurai","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, Kandang Kerbau Women's and Children's Hospital, Singapore, \n\nbDepartment of Neonatology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2025090515105684000_83.3.F168.1","first-page":"714","article-title":"The twin-twin transfusion.","volume":"76","author":"Blickstein","year":"1990","journal-title":"Obstet Gynecol"},{"key":"2025090515105684000_83.3.F168.2","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/0002-9378(90)90618-H","article-title":"Twin-twin transfusion.","volume":"163","author":"Urig","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"2025090515105684000_83.3.F168.3","first-page":"537","article-title":"Aggressive therapeutic amniocentesis for treatment of twin-twin transfusion.","volume":"77","author":"Urig","year":"1991","journal-title":"Obstet Gynecol"},{"key":"2025090515105684000_83.3.F168.4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0002-9378(89)90644-3","article-title":"Perinatal outcome in very preterm births with twin-twin transfusion.","volume":"161","author":"Shah","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"2025090515105684000_83.3.F168.5","doi-asserted-by":"crossref","first-page":"F48","DOI":"10.1136\/fn.73.1.F48","article-title":"Mechanism of visceral damage in fetofetal transfusion syndrome.","volume":"73","author":"Rehan","year":"1995","journal-title":"Arch Dis Child"},{"key":"2025090515105684000_83.3.F168.6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0095-5108(18)30731-0","article-title":"Neonatal problems in twins.","volume":"15","author":"McCulloch","year":"1988","journal-title":"Clin Perinatol"},{"key":"2025090515105684000_83.3.F168.7","first-page":"517","article-title":"Acute twin-twin transfusion: a possible mechanism for brain-damaged survivors after intrauterine death of a monochorionic twin.","volume":"78","author":"Fusi","year":"1991","journal-title":"Obstet Gynecol"},{"key":"2025090515105684000_83.3.F168.8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0095-5108(18)30722-X","article-title":"Placental considerations in multiple pregnancy.","volume":"15","author":"Bardawil","year":"1988","journal-title":"Clin Perinatol"},{"key":"2025090515105684000_83.3.F168.9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1479-828X.1996.tb02716.x","article-title":"Antepartum and postpartum complications of twin-twin transfusion.","volume":"36","author":"Cincotta","year":"1996","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2025090515105684000_83.3.F168.10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0002-9378(86)90338-8","article-title":"The role of feticide in the management of severe twin transfusion syndrome.","volume":"155","author":"Wittmann","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"2025090515105684000_83.3.F168.11","doi-asserted-by":"publisher","DOI":"10.1159\/000263286"},{"key":"2025090515105684000_83.3.F168.12","first-page":"690","article-title":"Selective second\u2013trimester termination of the anomalous fetus in twin pregnancies.","volume":"73","author":"Chitkara","year":"1989","journal-title":"Obstet Gynecol"},{"key":"2025090515105684000_83.3.F168.13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90395-3"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.83.3.F168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T22:50:48Z","timestamp":1757112648000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.83.3.F168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11,1]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,11,1]]},"published-print":{"date-parts":[[2000,11,1]]}},"alternative-id":["10.1136\/fn.83.3.F168"],"URL":"https:\/\/doi.org\/10.1136\/fn.83.3.f168","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11,1]]}}}