{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:04:18Z","timestamp":1789736658103,"version":"4.0.1"},"reference-count":17,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,4,28]]},"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To observe how the resonance frequency changes with the course of respiratory distress syndrome (RDS), by examining the effect of changing static compliance on the resonance frequency in premature infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In 12 ventilated premature infants with RDS (mean gestational age 26.6 weeks, mean birth weight 0.84 kg), resonance frequency and static compliance were determined serially using phase analysis and single breath mechanics technique respectively in the first seven days of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The minimum number of measurements done in any one baby was three and maximum was five in this seven day study period. The first measurement in each baby was done within the first 72 hours of life. The increase in compliance in this period varied from 27% to 179%. The variation in the corresponding resonance frequency was within 2 Hz in eight babies and within 6 Hz in all recruited babies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The resonance frequency of the respiratory system in preterm infants with RDS remains remarkably constant in the early stages of the illness, despite relatively large changes in static compliance.<\/jats:p>\n                  <jats:p>\n                     <jats:boxed-text position=\"float\">\n                        <jats:sec>\n                           <jats:title>Key messages<\/jats:title>\n                           <jats:def-list>\n                              <jats:def-item>\n                                 <jats:term>(1)<\/jats:term>\n                                 <jats:def>\n                                    <jats:p>HFOV decreases risk of barotrauma by reducing pressure swings in the airways during artificial ventilation<\/jats:p>\n                                 <\/jats:def>\n                              <\/jats:def-item>\n                              <jats:def-item>\n                                 <jats:term>(2)<\/jats:term>\n                                 <jats:def>\n                                    <jats:p>CO<jats:sub>2<\/jats:sub> elimination is dependent on the oscillating frequency<\/jats:p>\n                                 <\/jats:def>\n                              <\/jats:def-item>\n                              <jats:def-item>\n                                 <jats:term>(3)<\/jats:term>\n                                 <jats:def>\n                                    <jats:p>Resonance frequency is the frequency at which oscillatory ventilation is most efficient owing to the elimination of elastance through the mechanics of oscillation<\/jats:p>\n                                 <\/jats:def>\n                              <\/jats:def-item>\n                              <jats:def-item>\n                                 <jats:term>(4)<\/jats:term>\n                                 <jats:def>\n                                    <jats:p>Resonance frequency remains relatively stable despite significant changes in compliance in the early stages of respiratory distress syndrome<\/jats:p>\n                                 <\/jats:def>\n                              <\/jats:def-item>\n                              <jats:def-item>\n                                 <jats:term>(5)<\/jats:term>\n                                 <jats:def>\n                                    <jats:p>It is possible that resonance frequency can be incorporated as part of the management strategy to provide more efficient HFOV<\/jats:p>\n                                 <\/jats:def>\n                              <\/jats:def-item>\n                           <\/jats:def-list>\n                        <\/jats:sec>\n                     <\/jats:boxed-text>\n         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