{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:19:31Z","timestamp":1774563571939,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,8,17]]},"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Perinatal asphyxia is associated with cardiac dysfunction. This may be secondary to myocardial ischaemia. Cardiac troponin T is the ideal marker for myocardial necrosis. Elevated levels in cord blood may be associated with intrauterine hypoxia and increased perinatal morbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>To establish an upper limit of normal for cardiac troponin T concentration in the cord blood of infants. Relations between cardiac troponin T levels and other variables were investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Cord blood samples were collected from 242 infants and analysed. Data on gestation, birth weight, sex, Apgar scores, respiratory status, and mode of delivery were recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 242 samples were collected, and 215 samples from infants without respiratory distress were used to establish the 95th percentile of 0.050 ng\/ml. The gestation of these infants ranged from 31 to 42 weeks and birth weight ranged from 1.4 to 5 kg. There were no relations between cardiac troponin T levels and the other variables in these healthy infants. Twenty seven infants developed respiratory symptoms requiring oxygen and\/or ventilation. These infants had significantly higher cord cardiac troponin T levels than their healthy counterparts (median (interquartile range) 0.031 (0.010\u20130.084)<jats:italic>v<\/jats:italic> 0.010 (0.010\u20130.014) ng\/ml respectively; p\u2009&lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Cardiac troponin T levels in the cord blood are unaffected by gestation, birth weight, sex, or mode of delivery. Infants with respiratory distress had significantly higher cord cardiac troponin T levels, suggesting that cardiac troponin T may be a useful marker for myocardial damage in neonates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.84.1.f34","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F34-F37","source":"Crossref","is-referenced-by-count":46,"title":["Cardiac troponin T in cord blood"],"prefix":"10.1136","volume":"84","author":[{"given":"S J","family":"Clark","sequence":"first","affiliation":[{"name":"aUniversity of Liverpool, Liverpool, UK, \n\nbRoyal Liverpool Children's Hospital, Liverpool, \n\ncLiverpool Women's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Newland","sequence":"additional","affiliation":[{"name":"aUniversity of Liverpool, Liverpool, UK, \n\nbRoyal Liverpool Children's Hospital, Liverpool, \n\ncLiverpool Women's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C W","family":"Yoxall","sequence":"additional","affiliation":[{"name":"aUniversity of Liverpool, Liverpool, UK, \n\nbRoyal Liverpool Children's Hospital, Liverpool, \n\ncLiverpool Women's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N V","family":"Subhedar","sequence":"additional","affiliation":[{"name":"aUniversity of Liverpool, Liverpool, UK, \n\nbRoyal Liverpool Children's Hospital, Liverpool, \n\ncLiverpool Women's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"2025090515020548000_84.1.F34.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.1_Spec_No.17"},{"key":"2025090515020548000_84.1.F34.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80417-0"},{"key":"2025090515020548000_84.1.F34.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11551.x"},{"key":"2025090515020548000_84.1.F34.4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.10.1068"},{"key":"2025090515020548000_84.1.F34.5","first-page":"238","article-title":"Influence of acidosis, hypoxemia and hypotension on neurodevelopmental outcome in very low birth weight infants.","volume":"95","author":"Goldstein","year":"1995","journal-title":"Pediatrics"},{"key":"2025090515020548000_84.1.F34.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80841-0"},{"key":"2025090515020548000_84.1.F34.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1985.tb11036.x"},{"key":"2025090515020548000_84.1.F34.8","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(94)00065-4"},{"key":"2025090515020548000_84.1.F34.9","unstructured":"Anon (1999) Troponin T STAT data sheet. (Roche Diagnostics GmbH, Mannheim)."},{"key":"2025090515020548000_84.1.F34.10","first-page":"99","article-title":"Troponin T levels in the cord blood of healthy term neonates.","volume":"44","author":"Adamcova","year":"1995","journal-title":"Physiol Res"},{"key":"2025090515020548000_84.1.F34.11","first-page":"121","article-title":"Cardiac troponin T in pregnant women having intravenous tocolytic therapy.","volume":"262","author":"Adamcova","year":"1992","journal-title":"Arch Gynecol Obstet"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.84.1.F34","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T22:33:09Z","timestamp":1757111589000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.84.1.F34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,1,1]]},"published-print":{"date-parts":[[2001,1,1]]}},"alternative-id":["10.1136\/fn.84.1.F34"],"URL":"https:\/\/doi.org\/10.1136\/fn.84.1.f34","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1,1]]}}}