{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:04:10Z","timestamp":1780351450621,"version":"3.54.1"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,5,4]]},"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:p>The case is reported of a full term infant with severe microcephaly, overlapping sutures, prominence of the occipital bone, and scalp rugae. No other associated malformations were observed. The only obstetric history of interest was the performance of cordocentesis at 21 weeks gestational age because of low maternal \u03b1 fetoprotein levels. Ultrasound scans performed until then were normal. Cranial growth retardation was detected on ultrasound scanning at 25 weeks and intrauterine growth retardation as well as severe microcephaly at 34 weeks. Neuroimaging studies performed on the newborn infant showed intense cerebral atrophy in both hemispheres. Other complementary investigations gave negative results. A relation is proposed between the cordocentesis and the development of vascular disruption, which could have caused the fetal brain disruption sequence in this case.<\/jats:p>","DOI":"10.1136\/fn.84.1.f63","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F63-F64","source":"Crossref","is-referenced-by-count":11,"title":["Fetal brain disruption sequence in a newborn infant with a history of cordocentesis at 21 weeks gestation"],"prefix":"10.1136","volume":"84","author":[{"given":"N","family":"Vill\u00f3","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Hospital Principe de Asturias, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Beceiro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Principe de Asturias, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cebrero","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Principe de Asturias, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Garcia","family":"de Frias","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Principe de Asturias, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"2025090511575544000_84.1.F63.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320170213"},{"key":"2025090511575544000_84.1.F63.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82825-2"},{"key":"2025090511575544000_84.1.F63.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02079071"},{"key":"2025090511575544000_84.1.F63.4","doi-asserted-by":"publisher","DOI":"10.1159\/000023236"},{"key":"2025090511575544000_84.1.F63.5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/jnnp.17.4.295","article-title":"Case report: prenatal occlusion of the internal carotid artery.","volume":"17","author":"Clark","year":"1954","journal-title":"J Neurol Neurosurg Psychiat"},{"key":"2025090511575544000_84.1.F63.6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1469-8749.1965.tb10927.x","article-title":"Perinatal occlusion of the middle cerebral artery.","volume":"7","author":"Cocker","year":"1965","journal-title":"Dev Med Child Neurol"},{"key":"2025090511575544000_84.1.F63.7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1542\/peds.78.1.85","article-title":"Congenital microcephaly due to vascular disruption: in utero documentation.","volume":"78","author":"Hughes","year":"1986","journal-title":"Pediatrics"},{"key":"2025090511575544000_84.1.F63.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80739-8"},{"key":"2025090511575544000_84.1.F63.9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0002-9378(11)90761-3","article-title":"Complications of fetal blood sampling.","volume":"168","author":"Ghidini","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"2025090511575544000_84.1.F63.10","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1471-0528.1993.tb14308.x","article-title":"The effect of cordocentesis on umbilical and middle cerebral artery flow velocity waveforms.","volume":"100","author":"Hecher","year":"1993","journal-title":"Br J Obstet Gynecol"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.84.1.F63","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:07:40Z","timestamp":1757099260000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.84.1.F63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,1,1]]},"published-print":{"date-parts":[[2001,1,1]]}},"alternative-id":["10.1136\/fn.84.1.F63"],"URL":"https:\/\/doi.org\/10.1136\/fn.84.1.f63","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1,1]]}}}