{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:12:39Z","timestamp":1785499959882,"version":"3.56.0"},"reference-count":16,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,10,12]]},"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To determine the incidence of neonatal meningitis in England and Wales.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN<\/jats:title>\n                  <jats:p>A national postal survey using the British Paediatric Surveillance Unit (BPSU) card scheme supplemented by information from other sources.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SETTING<\/jats:title>\n                  <jats:p>England and Wales 1996\u20131997.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUBJECTS<\/jats:title>\n                  <jats:p>A total of 274 babies less than 28 days of age who were treated for meningitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The incidence of neonatal meningitis in England and Wales has not changed since our previous study in 1985\u20131987. However, the acute phase mortality has fallen from 19.8% in 1985\u20131987 to 6.6% in this study. Group B streptococci (42%) and <jats:italic>Escherichia coli<\/jats:italic>(16%) remain the most common infecting microorganisms. Eight of 69 (12%) babies with group B streptococci and 4\/26 (15%) with<jats:italic>E coli<\/jats:italic> died. Antibiotic regimens based on the third generation cephalosporins, notably cefotaxime, were most commonly used (84%). The BPSU scheme identified 72% of cases during the study period. Most cases of viral meningitis were not reported through the BPSU. Less than a third of samples from aseptic meningitis were examined for viruses; 56% of these were positive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Although the incidence of neonatal meningitis remains unchanged, mortality from this infection has fallen significantly. If this improvement is maintained as reflected in the level of sequelae at 5 years of age, then the fear surrounding meningitis during the neonatal period will have been dramatically reduced.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.84.2.f85","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F85-F89","source":"Crossref","is-referenced-by-count":131,"title":["Neonatal meningitis in England and Wales: 10 years on"],"prefix":"10.1136","volume":"84","author":[{"given":"D E","family":"Holt","sequence":"first","affiliation":[{"name":"The Karim Centre for Meningitis Research, Imperial College School of Medicine, Department of Paediatrics and Neonatal Medicine, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Halket","sequence":"additional","affiliation":[{"name":"The Karim Centre for Meningitis Research, Imperial College School of Medicine, Department of Paediatrics and Neonatal Medicine, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"de Louvois","sequence":"additional","affiliation":[{"name":"The Karim Centre for Meningitis Research, Imperial College School of Medicine, Department of Paediatrics and Neonatal Medicine, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Harvey","sequence":"additional","affiliation":[{"name":"The Karim Centre for Meningitis Research, Imperial College School of Medicine, Department of Paediatrics and Neonatal Medicine, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"2025090513342988000_84.2.F85.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.5.603"},{"key":"2025090513342988000_84.2.F85.2","doi-asserted-by":"crossref","first-page":"K75","DOI":"10.1136\/fn.71.2.F75","article-title":"Neonatal meningitis in England and Wales: a review of routine national data.","volume":"71","author":"Synott","year":"1991","journal-title":"Arch Dis Child"},{"key":"2025090513342988000_84.2.F85.3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.6.763"},{"key":"2025090513342988000_84.2.F85.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(99)80066-4"},{"key":"2025090513342988000_84.2.F85.5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.3.344"},{"key":"2025090513342988000_84.2.F85.6","unstructured":"Guy M Nicoll A Lynn R , eds (1998) British Paediatric Surveillance Unit. 12th Annual Report 1997\u20131998. 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