{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:44:43Z","timestamp":1791398683745,"version":"4.3.3"},"reference-count":30,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2001,1,30]]},"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To examine the relation between grade III\u2013IV periventricular\/intraventricular haemorrhage (PVH\/IVH) and antenatal exposure to tocolytic treatment in very low birthweight (VLBW) premature infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN<\/jats:title>\n                  <jats:p>The study population consisted of 2794 infants from the Israel National VLBW Infant Database, of gestational age 24\u201332 weeks, who had a cranial ultrasound examination during the first 28 days of life. Infants of mothers with pregnancy induced hypertension or those exposed to more than one tocolytic drug were excluded. Of the 2794 infants, 2013 (72%) had not been exposed to tocolysis and 781 (28%) had been exposed to a single tocolytic agent. To evaluate the effect of tocolysis and confounding variables on grade III\u2013IV PVH\/IVH, the \u03c7<jats:sup>2<\/jats:sup>test, univariate analysis, and a logistic regression model were used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 781 infants (28%) exposed to tocolysis, 341 (12.2%) were exposed to magnesium sulphate, 263 (9.4%) to ritodrine, and 177 (6.3%) to indomethacin. The overall incidence of grade III\u2013IV PVH\/IVH was 13.4%. In the multivariate logistic regression analysis, the following factors were related significantly and independently to grade III\u2013IV PVH\/IVH: no prenatal steroid treatment, low gestational age, one minute Apgar score 0\u20133, respiratory distress syndrome, patent ductus arteriosus, mechanical ventilation, and pneumothorax. Infants exposed to ritodrine tocolysis (but not to the other tocolytic drugs) were at significantly lower risk of grade III\u2013IV PVH\/IVH after adjustment for other variables (odds ratio\u2009=\u20090.3; 95% confidence interval 0.2 to 0.6).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>This study suggests that antenatal exposure of VLBW infants to ritodrine tocolysis, in contrast with tocolysis induced by magnesium sulphate or indomethacin, was associated with a lower incidence of grade III\u2013IV PVH\/IVH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.85.1.f13","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F13-F17","source":"Crossref","is-referenced-by-count":55,"title":["Effect of maternal tocolysis on the incidence of severe periventricular\/intraventricular haemorrhage in very low birthweight infants"],"prefix":"10.1136","volume":"85","author":[{"given":"Z","family":"Weintraub","sequence":"first","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Solovechick","sequence":"additional","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Reichman","sequence":"additional","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rotschild","sequence":"additional","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Waisman","sequence":"additional","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Davkin","sequence":"additional","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lusky","sequence":"additional","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Bental","sequence":"additional","affiliation":[{"name":"aNeonatal Department, Carmel Medical Center, Haifa, Israel, \n\nbHealth Services Research Institute, Ministry of Health, Gertner Institute, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"2025090510195771000_85.1.F13.1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(95)01692-9"},{"key":"2025090510195771000_85.1.F13.2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00003081-199538040-00008","article-title":"Risks and 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