{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:36:41Z","timestamp":1782290201272,"version":"3.54.5"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2000,9,11]]},"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To determine the incidence of catheter related thrombosis and to test the efficacy of recombinant tissue type plasminogen activator (rt-PA) in preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN<\/jats:title>\n                  <jats:p>From January 1995 to December 1998, echocardiography was performed in the first few days of life in 76 very low birthweight (\u2a7d\u20091500 g) infants out of a total of 147 having an umbilical catheter placed. When intracardiac thrombosis was diagnosed, rt-PA infusion was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Four infants (5%) developed an intracardiac thrombosis during the first few days of life. In three of them, rt-PA at a dose of 0.4\u20130.5 mg\/kg in a 20\u201330 minute bolus led to dissolution of the clot. One patient received a three hour infusion after the bolus, at a dose of 0.1 mg\/kg\/h, with resolution of the thrombus. No systemic effects were observed after rt-PA infusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Early thrombosis may occur as a complication of umbilical catheterisation in preterm infants; early echocardiographic detection of this disorder allows complete, safe, and rapid lysis with rt-PA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/fn.85.1.f66","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:40:22Z","timestamp":1027752022000},"page":"F66-F69","source":"Crossref","is-referenced-by-count":49,"title":["Early intracardiac thrombosis in preterm infants and thrombolysis with recombinant tissue type plasminogen activator"],"prefix":"10.1136","volume":"85","author":[{"given":"F","family":"Ferrari","sequence":"first","affiliation":[{"name":"aDepartment of Paediatrics, Division of Neonatology, Modena University, Italy, \n\nbDepartment of Embryology, Histology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vagnarelli","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatrics, Division of Neonatology, Modena University, Italy, \n\nbDepartment of Embryology, Histology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Gargano","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatrics, Division of Neonatology, Modena University, Italy, \n\nbDepartment of Embryology, Histology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Roversi","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatrics, Division of Neonatology, Modena University, Italy, \n\nbDepartment of Embryology, Histology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Biagioni","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatrics, Division of Neonatology, Modena University, Italy, \n\nbDepartment of Embryology, Histology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ranzi","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatrics, Division of Neonatology, Modena University, Italy, \n\nbDepartment of Embryology, Histology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G B","family":"Cavazzuti","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatrics, Division of Neonatology, Modena University, Italy, \n\nbDepartment of Embryology, Histology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"2025090503443684000_85.1.F66.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.5.449"},{"key":"2025090503443684000_85.1.F66.2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0022-3468(86)80364-5","article-title":"Thrombosis and infection complicating central venous catheterization in neonates.","volume":"9","author":"Girsoni","year":"1986","journal-title":"J Pediatr Surg"},{"key":"2025090503443684000_85.1.F66.3","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/oxfordjournals.eurheartj.a062020","article-title":"Right atrial thrombosis in two preterm infants: successful treatment with urokinase and heparin.","volume":"12","author":"Pongiglione","year":"1986","journal-title":"Eur Heart 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