{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:39:31Z","timestamp":1757615971372,"version":"3.44.0"},"reference-count":33,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2001,12,18]]},"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>Background: Lung fibrosis is thought to be important in chronic lung disease of prematurity (CLD).<\/jats:p>\n               <jats:p>Methods: Fibroblast proliferative activity was assessed in 207 bronchoalveolar lavage fluid (BALF) samples from 43 infants. Sixteen developed CLD (birth weight 765 g (630\u20131230), gestation 26.5 weeks (23\u201329)), 18 developed respiratory distress syndrome (RDS) (birth weight 1415 g (430\u20134160), gestation 31 weeks (23\u201339)), and nine control infants (birth weight 2110 g (900\u20133720), gestation 32 weeks (26\u201341)) received mechanical ventilation for non-pulmonary reasons.<\/jats:p>\n               <jats:p>Results: The fibroblast proliferative activity relative to 10% fetal calf serum was 64\u201375% in infants with CLD, 55\u201386% in the RDS group, and 42\u201368% in control infants during the first 5 weeks of life. Only at day 3 was there a difference between the groups (CLD 72% <jats:italic>v<\/jats:italic> control 42%, p &lt; 0.01; RDS 63% <jats:italic>v<\/jats:italic> control 42%, p &lt; 0.05). With the use of neutralising antibodies, platelet derived growth factor BB (PDGF-BB) and epidermal growth factor were undetectable, and insulin-like growth factor I (IGF-I) accounted for 14% (p &lt; 0.05) and 11% (p &lt; 0.005) of BALF mitogenic activity from the RDS and CLD groups respectively.<\/jats:p>\n               <jats:p>Conclusions: The mitogenic activity of BALF was similar in the three groups studied and was only partially accounted for by IGF-I. Growth factors other than PDGF-BB and IGF-I contribute significantly to this process.<\/jats:p>","DOI":"10.1136\/fn.86.3.f193","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:46:58Z","timestamp":1027752418000},"page":"F193-F197","source":"Crossref","is-referenced-by-count":5,"title":["Fibroblast mitogenic activity of lung lavage fluid from infants with chronic lung disease of prematurity"],"prefix":"10.1136","volume":"86","author":[{"given":"A E","family":"Currie","sequence":"first","affiliation":[{"name":"Department of Child Health, University of Leicester, Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Leicester, Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Leicester, Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Pandya","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Leicester, Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Leicester, Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Leicester, Leicester LE2 7LX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2002,5,1]]},"reference":[{"key":"2025090509383581000_86.3.F193.1","unstructured":"Kotecha S, Silverman M. Chronic respiratory complications of neonatal disorders. In: Landau LI, Taussig LM, eds. Textbook of pediatric respiratory medicine. St Louis, Missouri: Mosby, 1999:464\u2013521."},{"key":"2025090509383581000_86.3.F193.2","first-page":"14","volume":"12","year":"1997","journal-title":"Care of the Critically Ill"},{"key":"2025090509383581000_86.3.F193.3","first-page":"514","volume":"155","year":"1996","journal-title":"Eur J Pediatr"},{"key":"2025090509383581000_86.3.F193.4","unstructured":"Stocker JT. The respiratory tract. In: Stocker JT, Dehner LP, eds. Pediatric pathology. 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