{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:49:21Z","timestamp":1791308961655,"version":"4.3.1"},"reference-count":32,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2002,7,8]]},"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To study late onset systemic infections with coagulase negative staphylococci.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Prospective longitudinal study of coagulase negative staphylococcal infection in 18 Australasian neonatal nurseries.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> From 1991 to 2000 inclusive, there were 1281 cases of coagulase negative staphylococcal (CoNS) sepsis, comprising 57.1% of all late onset infections. The male\/female ratio was 1.27:1 (p &lt; 0.05). The incidence of CoNS sepsis was 3.46 episodes per 1000 live births. Most infected babies (71%) were 24\u201329 weeks gestation at birth (mode 26 weeks). The first positive culture was day 7\u201314 in 49% of babies (mode 10 days). Five cases of meningitis were reported, an incidence of 0.4% of all CoNS infections. Twenty nine babies (2.3%) had concurrent necrotising enterocolitis and CoNS septicaemia. Four babies (0.3%) died from CoNS infection, but CoNS infection possibly contributed to the death of an additional 20 babies (1.6%). The mortality directly attributable to CoNS infection was significantly lower than that from late onset infections with <jats:italic>Staphylococcus aureus<\/jats:italic> (13.1%; relative risk (RR) = 36.1 (95% confidence interval (CI) 13.0 to 100.2) or with Gram negative bacilli (14.2%; RR = 45.5 (95% CI 16.8 to 123.3)).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> CoNS are currently responsible for most late onset neonatal infections. Most infected babies are &lt; 30 weeks gestation at birth, and usually present between 7 and 14 days of age. CoNS infections may be associated with necrotising enterocolitis, although causality is unproven. Neonatal CoNS infections are relatively benign: meningitis is rare and mortality low compared with infection from other organisms. Over-vigorous attempts to reduce the incidence of CoNS infections using prophylactic antibiotics are not advisable.<\/jats:p>","DOI":"10.1136\/fn.88.2.f89","type":"journal-article","created":{"date-parts":[[2003,2,21]],"date-time":"2003-02-21T13:45:28Z","timestamp":1045835128000},"page":"F89-F93","source":"Crossref","is-referenced-by-count":157,"title":["A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units"],"prefix":"10.1136","volume":"88","author":[{"given":"D","family":"Isaacs","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Children's Hospital Westmead, Westmead, NSW 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2025090511593340000_88.2.F89.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70191-9"},{"key":"2025090511593340000_88.2.F89.2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1542\/peds.98.3.357","volume":"98","year":"1996","journal-title":"Pediatrics"},{"key":"2025090511593340000_88.2.F89.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1996.tb00914.x"},{"key":"2025090511593340000_88.2.F89.4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.5.1740-1746.2000"},{"key":"2025090511593340000_88.2.F89.5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1542\/peds.95.2.225","volume":"95","year":"1995","journal-title":"Pediatrics"},{"key":"2025090511593340000_88.2.F89.6","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199807000-00004"},{"key":"2025090511593340000_88.2.F89.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.6.1387"},{"key":"2025090511593340000_88.2.F89.8","unstructured":"Isaacs D, Moxon ER. 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