{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:15:14Z","timestamp":1791202514279,"version":"4.2.0"},"reference-count":23,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>\n                  <jats:bold>Objectives:<\/jats:bold> To study the effect of acute stress, caused by intrauterine needling at the intrahepatic vein (IHV), on fetal plasma concentrations of corticotrophin releasing hormone (CRH), and to compare paired fetal and maternal samples for CRH concentration to determine the extent of their joint control.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Venous blood samples were obtained from fetuses (gestational age 17\u201338 weeks) undergoing fetal blood sampling (n\u200a=\u200a29) or intrauterine transfusion (n\u200a=\u200a17) through either the IHV or the placental cord insertion (PCI).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> The Centre for Fetal Care, Queen Charlotte\u2019s and Chelsea Hospital, London, UK.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> Pregnant women undergoing clinically indicated fetal blood sampling or intrauterine blood\/platelet transfusion.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Fetal plasma cortisol increased with intrahepatic vein transfusion (mean (SD) cortisol response \u039464.7 (54.5) nmol\/l; p &lt; 0.0001, n\u200a=\u200a11), and fetal corticotrophin concentrations were higher after IHV (n\u200a=\u200a7) than PCI needling (n\u200a=\u200a6). Neither fetal nor maternal plasma CRH increased after IHV transfusion. Fetal CRH levels did not rise with gestation, whereas maternal CRH levels did (<jats:italic>r<\/jats:italic>\u200a=\u200a0.58; n\u200a=\u200a36; p &lt; 0.0001). There was a modest correlation between paired maternal and fetal values (<jats:italic>r<\/jats:italic>\u200a=\u200a0.36; n\u200a=\u200a36; p\u200a=\u200a0.03).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Acute fetal stress, caused by IHV needling of the fetal abdomen, resulted in hypothalamic-pituitary-adrenal axis activation, as shown by a rise in fetal cortisol and corticotrophin. However, it did not result in measurable CRH release into fetal plasma. This suggests that fetal plasma CRH is not derived from the hypophyseal-portal circulation, but from another source, presumably the placenta.<\/jats:p>","DOI":"10.1136\/fn.89.1.f29","type":"journal-article","created":{"date-parts":[[2004,1,10]],"date-time":"2004-01-10T12:37:42Z","timestamp":1073738262000},"page":"F29-F32","source":"Crossref","is-referenced-by-count":76,"title":["Human fetal and maternal corticotrophin releasing hormone responses to acute stress"],"prefix":"10.1136","volume":"89","author":[{"given":"R","family":"Gitau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N M","family":"Fisk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Glover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2004,1,1]]},"reference":[{"key":"2025090509595363000_89.1.F29.1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-5-1054"},{"key":"2025090509595363000_89.1.F29.2","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0002-9378(88)80162-5","volume":"159","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"2025090509595363000_89.1.F29.3","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1159\/000126302","volume":"56","year":"1992","journal-title":"Neuroendocrinology"},{"key":"2025090509595363000_89.1.F29.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(98)00023-0"},{"key":"2025090509595363000_89.1.F29.5","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1140497"},{"key":"2025090509595363000_89.1.F29.6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1515\/jpme.1996.24.3.243","volume":"24","year":"1996","journal-title":"J Perinat Med"},{"key":"2025090509595363000_89.1.F29.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91279-3"},{"key":"2025090509595363000_89.1.F29.8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1203\/00006450-199904010-00007","volume":"45","year":"1999","journal-title":"Pediat Res"},{"key":"2025090509595363000_89.1.F29.9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.1.104"},{"key":"2025090509595363000_89.1.F29.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70340-6"},{"key":"2025090509595363000_89.1.F29.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60824-0"},{"key":"2025090509595363000_89.1.F29.12","unstructured":"Jezova D, Kvetnansky R, Tilders F, et al. Interaction of circulating catecholamines, CRF and AVP in the control of ACTH release during stress. In: Van Loon G, Kvetnansky R, McCarty R, et al. Stress. Neurochemical and Humoral mechanisms, Vol 1. New York: Gordon and Breach Science Publishers, 1989."},{"key":"2025090509595363000_89.1.F29.13","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1998.0357"},{"key":"2025090509595363000_89.1.F29.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06354.x"},{"key":"2025090509595363000_89.1.F29.15","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3159"},{"key":"2025090509595363000_89.1.F29.16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0143-4004(91)90015-8","volume":"12","year":"1991","journal-title":"Placenta"},{"key":"2025090509595363000_89.1.F29.17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00770.x"},{"key":"2025090509595363000_89.1.F29.18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.4.1376"},{"key":"2025090509595363000_89.1.F29.19","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0461"},{"key":"2025090509595363000_89.1.F29.20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-2007-994641","volume":"10","year":"1993","journal-title":"Am J Perinatol"},{"key":"2025090509595363000_89.1.F29.21","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-5-1199"},{"key":"2025090509595363000_89.1.F29.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)80011-2"},{"key":"2025090509595363000_89.1.F29.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70707-6"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/fn.89.1.F29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:01:25Z","timestamp":1757091685000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/fn.89.1.F29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,1,1]]},"published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1136\/fn.89.1.F29"],"URL":"https:\/\/doi.org\/10.1136\/fn.89.1.f29","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}