{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:22:13Z","timestamp":1788380533398,"version":"build-2803163510"},"reference-count":30,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Prospective observational study.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Regional neonatal intensive care unit.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> Thirty five ventilated preterm babies &lt; 33 weeks gestation, seven of whom were born after chorioamnionitis, which was diagnosed histologically as the presence of inflammatory cells in the chorioamnionic plate.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> MMP-8 was measured by enzyme linked immunosorbent assay (ELISA) in 90 serial BAL samples taken during the first six postnatal days. The median MMP-8 concentration for each baby was calculated.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Median MMP-8 concentrations were higher in the chorioamnionitis group than in those without (43 <jats:italic>v<\/jats:italic> 5 ng\/ml). Partial or complete courses of antenatal corticosteroids had no effect on MMP-8 concentrations.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Higher concentrations of MMP-8 are found in BAL fluid from preterm babies from pregnancies complicated by chorioamnionitis. This type I collagenase may contribute to the lung injury that occurs in some babies with respiratory distress syndrome.<\/jats:p>","DOI":"10.1136\/fn.89.1.f61","type":"journal-article","created":{"date-parts":[[2004,1,10]],"date-time":"2004-01-10T12:37:42Z","timestamp":1073738262000},"page":"F61-F64","source":"Crossref","is-referenced-by-count":17,"title":["Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies"],"prefix":"10.1136","volume":"89","author":[{"given":"A E","family":"Curley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D G","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K J","family":"MacMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C 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