{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:10:16Z","timestamp":1793502616803,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Shanghai Pujiang Program","award":["17PJD038"],"award-info":[{"award-number":["17PJD038"]}]},{"name":"Shanghai health system excellent talent training program (excellent subject leader) project","award":["2017BR054"],"award-info":[{"award-number":["2017BR054"]}]},{"name":"Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support","award":["20172029"],"award-info":[{"award-number":["20172029"]}]},{"name":"Collaborative Innovation Center for Translational Medicine at Shanghai Jiao Tong University School of Medicine","award":["TM201728"],"award-info":[{"award-number":["TM201728"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81571298"],"award-info":[{"award-number":["81571298"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With an aggravated social ageing level, the number of patients with Alzheimer\u2019s disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer\u2019s disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>20 AD patients, 21 aMCIs and 25\u00a0NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2018-100005","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T06:47:09Z","timestamp":1555483629000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Study of brain morphology change in Alzheimer\u2019s disease and amnestic mild cognitive impairment compared with normal controls"],"prefix":"10.1002","volume":"32","author":[{"given":"Huanqing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China"},{"name":"Alzheimer's Disease and Related Disorders Center Shanghai Jiao Tong University Shanghai 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China"},{"name":"Alzheimer's Disease and Related Disorders Center Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China"},{"name":"Alzheimer's Disease and Related Disorders Center Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China"},{"name":"Alzheimer's Disease and Related Disorders Center Shanghai Jiao Tong University Shanghai 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