{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:08Z","timestamp":1787017088914,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Shanghai Huangpu District research project \u201cCorrelation study of different dimensions of mental behavior symptoms in patients with dementia and the mood disorder in their caregivers\u201d","award":["HKM201721"],"award-info":[{"award-number":["HKM201721"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>The population of early\u2010onset Alzheimer\u2019s disease (EOAD) accounts for 1%\u20132% of the total population of Alzheimer\u2019s disease, and genetic mutations are more common in EOAD. The first symptom of the patient in the present case report was the decline in memories of recent events, and the disease progressed rapidly in the following 2\u2009years. Genetic testing has revealed the presence of genetic mutations (c.A479G, p.N160S) of ACE, which causes the 160th codon of the ACE protein to change from aspartic acid to serine, and at the same time genotype of apolipoprotein E (APOE) is \u025b3\/\u025b4. We think that this patient carries the mutation type of the sensitive gene ACE and the risk gene APOE of Alzheimer\u2019s disease, and this is the reason why the disease progressed rapidly. Moreover, we discussed ACE genetic mutation\u2019s meaning in EOAD progression.<\/jats:p>","DOI":"10.1136\/gpsych-2018-100028","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T06:35:21Z","timestamp":1571639721000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["ACE gene missense mutation in a case with early\u2010onset, rapid progressing dementia"],"prefix":"10.1002","volume":"32","author":[{"given":"Jing","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Psychiatry Shanghai Huangpu District Mental Health Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China"},{"name":"Alzheimer\u2019s Disease and Related Disorders Center Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China"},{"name":"Alzheimer\u2019s Disease and Related Disorders Center Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Deparment of Geriatric Psychiatry Shanghai Mental Health Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-007-1006-x"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.09.016"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23738"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00127-7"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000383"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.4238\/2015.February.6.5"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku340"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/356083a0"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560020916"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228148"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2019-100054"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.06.006"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.215.295"},{"key":"e_1_2_10_16_2","first-page":"47","article-title":"Genetic variation and pharmacogenomics in Alzheimer disease","volume":"105","author":"Cacabelos R","year":"2003","journal-title":"Seishin Shinkeigaku Zasshi"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0444-x"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.07.015"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002156"}],"container-title":["General Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/gpsych-2018-100028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1136\/gpsych-2018-100028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/gpsych-2018-100028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:34:42Z","timestamp":1775644482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1136\/gpsych-2018-100028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/gpsych-2018-100028"],"URL":"https:\/\/doi.org\/10.1136\/gpsych-2018-100028","archive":["Portico"],"relation":{},"ISSN":["2096-5923","2517-729X"],"issn-type":[{"value":"2096-5923","type":"print"},{"value":"2517-729X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"article-number":"e100028"}}