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Psychiatry"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neural oscillations directly reflect the rhythmic changes of brain activities during the resting state or while performing specific tasks. Abnormal neural oscillations have been discovered in patients with schizophrenia. However, there is limited evidence available on abnormal spontaneous neural oscillations in clinical high risk for psychosis (CHR\u2010P). The brain signals recorded by the magnetoencephalography (MEG) technique are not to be disrupted by the skull and scalp.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we applied the MEG technique to record the resting\u2010state neural activities in CHR\u2010P. This was followed by a detailed MEG analysis method including three steps: (1) preprocessing, which was band\u2010pass filtering based on the 0.5\u201360\u2009Hz frequency range, removal of 50\u2009Hz power frequency interference, and removal of electrocardiography (ECG) and electrooculography (EOG) artefacts by independent component analysis; (2) time\u2010frequency analysis, a multitaper time\u2010frequency transformation based on the Hanning window, and (3) source localisation, an exact low\u2010resolution brain electromagnetic tomography. The method was verified by comparing a participant with CHR\u2010P with a healthy control during the MEG recordings with an eyes\u2010closed resting state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Experimental results show that the neural oscillations in CHR\u2010P were significantly abnormal in the theta frequency band (4\u20137\u2009Hz) and the delta frequency band (1\u20133\u2009Hz). Also, relevant brain regions were located in the left occipital lobe and left temporo\u2010occipital junction for the theta band and in the right dorsolateral prefrontal lobe and near orbitofrontal gyrus for the delta band.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Abnormal neural oscillations based on specific frequency bands and corresponding brain sources may become biomarkers for high\u2010risk groups. Further work will validate these characteristics in CHR\u2010P cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2021-100712","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T12:40:29Z","timestamp":1653309629000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Abnormal neural oscillations in clinical high risk for psychosis: a magnetoencephalography method study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-2836","authenticated-orcid":false,"given":"Yegang","family":"Hu","sequence":"first","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of 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