{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:04:53Z","timestamp":1792145093102,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adverse childhood experiences have a significant impact on different mental disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross\u2010disorder manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 1513\u00a0individuals aged \u226518 years : 339 patients with substance use disorders, 125 patients with schizophrenia, 342 patients with depression, 136 patients with bipolar disorder, 431 patients with obsessive\u2010compulsive disorder (OCD), and 140 healthy controls. The Early Trauma Inventory Self Report\u2010Short Form was used to investigate childhood traumatic experiences, and the Addiction Severity Index, Positive and Negative Syndrome Scale, Hamilton Depression Scale, Young Mania Rating Scale, and Yale\u2010Brown Obsessive\u2010Compulsive Scale were used to assess mental disorder severity. Correlation and multivariate logistic regression were analysed between adverse childhood experiences and clinical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Levels of adverse childhood experiences were significantly different among different mental disorders. Moreover, 25.8% of patients with substance use disorders reported childhood trauma, which was significantly higher than found in the other four psychiatric disorder groups. Emotional abuse scores were positively correlated with disease severity: the higher the total trauma score, the more severe the mental disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adverse childhood experiences are a common phenomenon in those with mental disorders, and the level of trauma affects mental disorder severity. Emotional abuse is closely related to many mental disorders. The incidence or severity of mental disorders can be reduced in the future by reducing the incidence of adverse childhood experiences or by timely intervention in childhood trauma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2021-100741","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T11:38:25Z","timestamp":1653305905000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross\u2010diagnostic study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-7073","authenticated-orcid":false,"given":"Wenjie","family":"Gu","sequence":"first","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghui","family":"Yi","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-5314","authenticated-orcid":false,"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2663"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.3155"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/17522439.2011.626867"},{"key":"e_1_2_14_5_2","first-page":"1","article-title":"The relationship between childhood trauma and clinical characteristics in ultrahigh risk for psychosis youth","volume":"11","author":"Vos Cde","year":"2019","journal-title":"Psychosis"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.194019"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.05.003"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.08.038"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720000914"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0827-4"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00149"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.07.022"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/01634372.2017.1362091"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.4493"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.12.045"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs050"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20330"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10101531"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw163"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2012.06.009"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2021-100659"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2010.05.017"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.09.021"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2015.1101467"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2016.1261899"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.12.027"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.194019"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.12.019"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00042"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2021-100553"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-013-0519-5"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.11.028"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10597-005-2600-x"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.12.225"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00813.x"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.02.009"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.12.054"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-013-0787-7"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.08.012"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2011.06.015"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710001005"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.5993\/AJHB.36.3.11"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000559"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198507000-00005"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000291514"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1981.tb00676.x"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200211000-00017"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(94)90039-6"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.5765\/jkacap.2018.29.1.2"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2019.08.004"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13268"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000243824.84651.6c"},{"key":"e_1_2_14_53_2","volume-title":"Preventing child maltreatment: a guide to taking action and generating evidence","author":"World Health Organization, International Society for Prevention of Child Abuse and Neglect","year":"2006"},{"key":"e_1_2_14_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000154"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.11.025"},{"key":"e_1_2_14_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.05.014"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2270"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.10.054"},{"key":"e_1_2_14_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.01.013"},{"key":"e_1_2_14_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/14659891.2018.1489478"},{"key":"e_1_2_14_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14334"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.3155"}],"container-title":["General Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/gpsych-2021-100741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1136\/gpsych-2021-100741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/gpsych-2021-100741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:33:10Z","timestamp":1775644390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1136\/gpsych-2021-100741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/gpsych-2021-100741"],"URL":"https:\/\/doi.org\/10.1136\/gpsych-2021-100741","archive":["Portico"],"relation":{},"ISSN":["2096-5923","2517-729X"],"issn-type":[{"value":"2096-5923","type":"print"},{"value":"2517-729X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"article-number":"e100741"}}