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Psychiatry"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brain\u2010derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)\u2010induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH\u2010dependent individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of the study was to investigate changes in BDNF levels during METH self\u2010administration in monkeys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure. Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self\u2010administration in the three monkeys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Repeated METH exposure decreased plasma BDNF levels. Additionally, plasma BDNF decreased with long\u2010term rather than short\u2010term accumulation of METH during METH self\u2010administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2023-101127","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:10:14Z","timestamp":1698729014000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Repeated methamphetamine exposure decreases plasma brain\u2010derived neurotrophic factor levels in rhesus monkeys"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-7082","authenticated-orcid":false,"given":"Wenlei","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Su","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lingang Laboratory Shanghai 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