{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:53:18Z","timestamp":1790877198735,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201702"],"award-info":[{"award-number":["82201702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001405"],"award-info":[{"award-number":["82001405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"and the Hunan Natural Science Foundation Youth Program","award":["2021JJ40979"],"award-info":[{"award-number":["2021JJ40979"]}]},{"name":"Youth Science Foundation of Xiangya Hospital","award":["2020Q20"],"award-info":[{"award-number":["2020Q20"]}]},{"name":"the clinical research fundation of the National Clinical Research Center for Geriatric Diseases","award":["2020LNJJ01"],"award-info":[{"award-number":["2020LNJJ01"]}]},{"name":"Science and Technology Innovation Team Talent Project of Hunan Province","award":["2021 RC4056"],"award-info":[{"award-number":["2021 RC4056"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201702, 82001405"],"award-info":[{"award-number":["82201702, 82001405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Understanding synaptic alteration in obsessive\u2010compulsive disorder (OCD) is crucial for elucidating its pathological mechanisms, but\n                      <jats:italic>in vivo<\/jats:italic>\n                      research on this topic remains limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to identify the synaptic density indicators in OCD and explore the relationship between cognitive dysfunction and synaptic density changes in OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study enrolled 28 drug\u2010naive adults with OCD aged 18\u201340 years and 16 healthy controls (HCs). Three\u2010dimensional T1\u2010weighted structural magnetic resonance imaging and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010SynVesT\u20101 positron emission tomography were conducted. Cognitive function was assessed using the Wisconsin Cart Sorting Test (WCST) in patients with OCD and HCs. Correlative analysis was performed to examine the association between synaptic density reduction and cognitive dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HCs, patients with OCD showed reduced synaptic density in regions of the cortico\u2010striato\u2010thalamo\u2010cortical circuit such as the bilateral putamen, left caudate, left parahippocampal gyrus, left insula, left parahippocampal gyrus and left middle occipital lobe (voxel p&lt;0.001, uncorrected, with cluster level above 50 contiguous voxels). The per cent conceptual\u2010level responses of WCST were positively associated with the synaptic density reduction in the left middle occipital gyrus (R\n                      <jats:sup>2<\/jats:sup>\n                      =0.1690, p=0.030), left parahippocampal gyrus (R\n                      <jats:sup>2<\/jats:sup>\n                      =0.1464, p=0.045) and left putamen (R\n                      <jats:sup>2<\/jats:sup>\n                      =0.1967, p=0.018) in patients with OCD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Adults with OCD demonstrated lower\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010labelled difluoro analogue of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010SynVesT\u20101 compared with HCs, indicating potentially lower synaptic density. This is the first study to explore the synaptic density in patients with OCD and provides insights into potential biological targets for cognitive dysfunctions in OCD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2023-101208","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T04:30:14Z","timestamp":1718598614000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Lower synaptic density and its association with cognitive dysfunction in patients with obsessive\u2010compulsive disorder"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-0548","authenticated-orcid":false,"given":"Qian","family":"Xiao","sequence":"first","affiliation":[{"name":"Mental Health Center Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyou","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixi","family":"Dong","sequence":"additional","affiliation":[{"name":"Mental Health Center Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0998-8943","authenticated-orcid":false,"given":"Shuo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Biological Nanotechnology National Health Commission Changsha Hunan China"},{"name":"National Clinical Research Center Geriatric Disorders (Xiangya) Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/psychiatry.IndianJPsychiatry_525_18"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2020.102343"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09562-7"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0431-3"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0302-7"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.43"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-020-00721-2"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-013-0416-x"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.9.6.448"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_13_12_2","volume-title":"Structured 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