{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:29:55Z","timestamp":1783700995714,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2022ZD026"],"award-info":[{"award-number":["YG2022ZD026"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771461"],"award-info":[{"award-number":["81771461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071545"],"award-info":[{"award-number":["82071545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20Y11906500"],"award-info":[{"award-number":["20Y11906500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"two hospital-level research projects of Shanghai Mental Health Center","award":["2020- YJ09"],"award-info":[{"award-number":["2020- YJ09"]}]},{"name":"two hospital-level research projects of Shanghai Mental Health Center","award":["2020-QH-04"],"award-info":[{"award-number":["2020-QH-04"]}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2022ZD026"],"award-info":[{"award-number":["YG2022ZD026"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth project of Shanghai Health Commission","award":["20224Y0267"],"award-info":[{"award-number":["20224Y0267"]}]},{"name":"Shanghai Clinical Medical Research Center for Psychiatric and Psychological Disorders","award":["19MC1911100"],"award-info":[{"award-number":["19MC1911100"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771461"],"award-info":[{"award-number":["81771461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071545"],"award-info":[{"award-number":["82071545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20Y11906500"],"award-info":[{"award-number":["20Y11906500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) has been characterised as a psychiatric disorder associated with increased control. Currently, it remains difficult to predict treatment response in patients with AN. Their cognitive abilities are known to be resistant to treatment. It has been established that the frontoparietal control network (FPCN) is the direct counterpart of the executive control network. Therefore, the resting\u2010state brain activity of the FPCN may serve as a biomarker to predict treatment response in AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study aimed to investigate the association between resting\u2010state functional connectivity (RSFC) of the FPCN, clinical symptoms and treatment response in patients with AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case\u2010control study, 79 female patients with AN and no prior treatment from the Shanghai Mental Health Center and 40\u00a0matched healthy controls (HCs) were recruited from January 2015 to March 2022. All participants completed the Questionnaire Version of the Eating Disorder Examination (version 6.0) to assess the severity of their eating disorder symptoms. Additionally, RSFC data were obtained from all participants at baseline by functional magnetic resonance imaging. Patients with AN underwent routine outpatient treatment at the 4th and 12th week, during which time their clinical symptoms were evaluated using the same measures as at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 79 patients, 40 completed the 4\u2010week follow\u2010up and 35 completed the 12\u2010week follow\u2010up. The RSFC from the right posterior parietal cortex (PPC) and dorsolateral prefrontal cortex (dlPFC) increased in 79 patients with AN vs 40 HCs after controlling for depression and anxiety symptoms. By multiple linear regression, the RSFC of the PPC to the inferior frontal gyrus was found to be a significant factor for self\u2010reported eating disorder symptoms at baseline and the treatment response to cognitive preoccupations about eating and body image, after controlling for age, age of onset and body mass index. The RSFC in the dlPFC to the middle temporal gyrus and the superior frontal gyrus may be significant factors in the treatment response to binge eating and loss of control\/overeating in patients with AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Alterations in RSFC in the FPCN appear to affect self\u2010reported eating disorder symptoms and treatment response in patients with AN. Our findings offer new insight into the pathogenesis of AN and could promote early prevention and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2023-101389","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T22:40:15Z","timestamp":1716849615000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Association between the frontoparietal network, clinical symptoms and treatment response in individuals with untreated anorexia nervosa"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-9183","authenticated-orcid":false,"given":"Qianqian","family":"He","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Department of Clinical Psychology Shanghai Pudong New Area Mental Health Center Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9735-5657","authenticated-orcid":false,"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Psychotic Disorders Brain Health Institute National Center for Mental Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning and IDG\/McGovern Institute for Brain Research Beijing Normal University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-0189","authenticated-orcid":false,"given":"Ling","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-9687","authenticated-orcid":false,"given":"Sufang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-5314","authenticated-orcid":false,"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61748-7"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13261"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2602"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.01.003"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311772110"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01660-9"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00346"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00356-9"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08050775"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124027"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2019.103441"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2682"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0071"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.09.074"},{"key":"e_1_2_15_17_2","first-page":"350","article-title":"Validity and reliability of the Chinese version of the eating disorder examination questionnaire 6.0\u00a0in female patients with eating disorders (in Chinese)","volume":"31","author":"Lian GU","year":"2017","journal-title":"Chin Ment Health J"},{"key":"e_1_2_15_18_2","first-page":"110","article-title":"Reliability and validity of depression scales of Chinese version: a systematic review","volume":"38","author":"Sun XY","year":"2017","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1359105316658971"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.08.021"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-011-0083-5"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.332"},{"key":"e_1_2_15_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.087"},{"key":"e_1_2_15_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666171017111532"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14352"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22731"},{"key":"e_1_2_15_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2023.01.022"},{"key":"e_1_2_15_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2023-101144"},{"key":"e_1_2_15_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23597"},{"key":"e_1_2_15_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10016"},{"key":"e_1_2_15_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-015-0559-z"}],"container-title":["General Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/gpsych-2023-101389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1136\/gpsych-2023-101389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1136\/gpsych-2023-101389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:34:37Z","timestamp":1775644477000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1136\/gpsych-2023-101389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1136\/gpsych-2023-101389"],"URL":"https:\/\/doi.org\/10.1136\/gpsych-2023-101389","archive":["Portico"],"relation":{},"ISSN":["2096-5923","2517-729X"],"issn-type":[{"value":"2096-5923","type":"print"},{"value":"2517-729X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"article-number":"e101389"}}