{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:17:12Z","timestamp":1790299032497,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det f\u00f6r h\u00e4lsa, arbetsliv och v\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2019\u201000105 and 2021\u201001862"],"award-info":[{"award-number":["2019\u201000105 and 2021\u201001862"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"FORTE","doi-asserted-by":"crossref","award":["2019-00105 and 2021-01862"],"award-info":[{"award-number":["2019-00105 and 2021-01862"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The knowledge about the prevalence of schizophrenia among people with intellectual disabilities (ID) is sparse, particularly concerning the distribution in different age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the prevalence of diagnoses in the schizophrenia spectrum among people with ID compared with the general population (gPop).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an 8\u2010year longitudinal register study. The participants were all residents of Sk\u00e5ne on 1\u00a0January 2014. People with a diagnosis of ID (F7\u00a0in International Statistical Classification of Diseases and Related Health Problems 10th Revision) or Down syndrome (DS; Q90), or service and support for people with ID\/autism spectrum disorder (ASD) comprised the ID cohort (n=14 716). After excluding family members of people in the ID cohort, the remaining population of Sk\u00e5ne comprised the gPop cohort (n=1 226 955).<\/jats:p>\n                    <jats:p>The primary outcome measure was having at least one diagnosis in the schizophrenia spectrum (F20\u2010F29). Secondary outcomes were single diagnoses within the schizophrenia spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of schizophrenia spectrum diagnoses was 7.2% in the ID cohort. This was more than an eightfold increase compared with the gPop (relative risk (RR) 8.45; 95% CI 7.94 to 9.00). The risk was also high among children (aged 0\u201318 years at the start of the study period; RR 9.42; 95% CI 7.36 to 12.05). In the subcohort comprising those with a diagnosis of DS, the risk of schizophrenia diagnosis was more than twice as high as in gPop. Concomitant ASD or genetic syndrome did not carry an excess risk among people with ID when compared with the gPop.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of the present study support earlier assumptions that people with vulnerable brains develop psychotic disorders more frequently and that the onset age is lower than among people in the gPop. Habilitation services for children and adolescents, as well as general mental health services, should keep in mind that schizophrenia may be present when children and adolescents show severely decreased functioning, anxiety or aggressive behaviour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2024-101673","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T23:16:40Z","timestamp":1734045400000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Schizophrenia in children, adults and older people with intellectual disability compared with the general population: a Swedish register study (IDcare)"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-6202","authenticated-orcid":false,"given":"Trine Lise","family":"Bakken","sequence":"first","affiliation":[{"name":"Mental Health Addiction Oslo University Hospital Oslo Norway"},{"name":"Health Sciences Oslo Metropolitan University Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8915-8730","authenticated-orcid":false,"given":"Magnus","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4539-8337","authenticated-orcid":false,"given":"Anna","family":"Axmon","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Medicine Laboratory Medicine Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jar.13127"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.044461"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.106.022483"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0578-7"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.24869\/psyd.2020.320"},{"key":"e_1_2_13_7_2","unstructured":"World Health Organization.The ICD\u201011 classification of mental and behavioral disorders. 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