{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:05:47Z","timestamp":1793815547261,"version":"4.6.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72374014"],"award-info":[{"award-number":["72374014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871854"],"award-info":[{"award-number":["81871854"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Jiao Tong University Young Talent Cultivation Program in Liberal Arts","award":["2024QN041"],"award-info":[{"award-number":["2024QN041"]}]},{"name":"Shanghai Jiao Tong University School of Medicine: Nursing Development Program","award":["SJTUHLXK2024"],"award-info":[{"award-number":["SJTUHLXK2024"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72374014"],"award-info":[{"award-number":["72374014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871854"],"award-info":[{"award-number":["81871854"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key R&D Program of China","award":["2020YFC2008804"],"award-info":[{"award-number":["2020YFC2008804"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gen. Psychiatry"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence on the effects of different exercise interventions on cognitive function is insufficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the feasibility and effects of remotely supervised aerobic exercise (AE) and resistance exercise (RE) interventions in older adults with mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a 6\u2010month pilot three\u2010arm randomised controlled trial. Eligible participants (n=108) were recruited and randomised to the AE group, RE group or control (CON) group with a 1:1:1 ratio. Interventions were delivered at home with remote supervision. We evaluated participants\u2019 global cognition, memory, executive function, attention, physical activity levels, physical performance and muscle strength of limbs at baseline, 3\u2009months (T1) and 6\u2009months (T2) after randomisation. A linear mixed\u2010effects model was adopted for data analyses after controlling for covariates. Tukey\u2019s method was used for adjusting for multiple comparisons. Sensitivity analyses were performed after excluding individuals with low compliance rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>15 (13.89%) participants dropped out. The median compliance rates in the AE group and RE group were 67.31% and 93.27%, respectively. After adjusting for covariates, the scores of the Alzheimer\u2019s Disease Assessment Scale\u2010Cognitive subscale in the AE group decreased by 2.04 (95% confidence interval (CI) \u22123.41 to \u22120.67, t=\u22122.94, p=0.004) and 1.53 (95% CI \u22122.88 to \u22120.17, t=\u22122.22, p=0.028) points more than those in the CON group at T1 and T2, respectively. The effects of AE were still significant at T1 (estimate=\u22121.70, 95% CI \u22123.20 to \u22120.21, t=\u22122.69, p=0.021), but lost statistical significance at T2 after adjusting for multiple comparisons. As for executive function, the Stroop time interference in the RE group decreased by 11.76 s (95% CI \u221221.62 to \u22121.90, t=\u22122.81, p=0.015) more than that in the AE group at T2 after Tukey\u2019s adjustment. No other significant effects on cognitive functions were found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both remotely supervised AE and RE programmes are feasible in older adults with MCI. AE has positive effects on global cognition, and RE improves executive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ChiCTR2100045582.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gpsych-2024-101858","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T02:12:07Z","timestamp":1742955127000},"update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Feasibility and effects of remotely supervised aerobic training and resistance training in older adults with mild cognitive impairment: a pilot three\u2010arm randomised controlled trial"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-9087","authenticated-orcid":false,"given":"Xiuxiu","family":"Huang","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University School of Nursing Shanghai China"},{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulian","family":"Bao","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lan","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"An","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Arizona State University Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqin","family":"Wan","sequence":"additional","affiliation":[{"name":"Peking University School of Nursing Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_16_2_2","unstructured":"World Health Organization.Dementia.2023. 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